光氧化还原催化的多组分 Petasis 反应的连续流方案。
A continuous-flow protocol for photoredox-catalyzed multicomponent Petasis reaction.
机构信息
Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.
Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya street 6, Moscow 117198, Russia.
出版信息
STAR Protoc. 2022 Feb 5;3(1):101162. doi: 10.1016/j.xpro.2022.101162. eCollection 2022 Mar 18.
Here, we present a robust protocol for the facile and rapid synthesis of functionalized secondary amines in continuous flow. More specifically, we describe a detailed guide to perform a photocatalyzed Petasis reaction within 50 min using alkyl boronic acid as radical precursor and a Vapourtec E-series as key equipment. The desired functionalized amine has been synthesized in mmol scale and with a productivity rate of 0.2 mmol/h. The protocol is limited to alkyl boronic acids. For complete details on the generation and use of this protocol, please refer to Oliva et al. (2021).
在这里，我们提出了一种在连续流中简便快速合成功能化仲胺的稳健方案。更具体地说，我们描述了一种详细的指南，使用烷基硼酸作为自由基前体，并使用 Vapourtec E 系列作为关键设备，在 50 分钟内进行光催化 Petasis 反应。所需的功能化胺已在 mmol 规模下合成，产率为 0.2 mmol/h。该方案仅限于烷基硼酸。有关该方案的生成和使用的完整详细信息，请参阅 Oliva 等人（2021 年）。
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