Broad Institute of Harvard and MIT, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Angew Chem Int Ed Engl. 2011 Aug 22;50(35):8172-5. doi: 10.1002/anie.201103271. Epub 2011 Jul 12.
Multicomponent Petasis reactions: the first diastereoselective Petasis reaction catalyzed by chiral biphenols that enables the synthesis of syn and anti β-amino alcohols in pure form has been developed. The reaction exploits a multicomponent approach that involves boronates, α-hydroxy aldehydes, and amines.
多组分 Petasis 反应：首次发展了手性联苯酚催化的非对映选择性 Petasis 反应，可实现纯形式的 syn 和 anti-β-氨基醇的合成。该反应利用了硼酸盐、α-羟基醛和胺的多组分方法。
