催化非对映选择性佩替斯反应。
Catalytic diastereoselective petasis reactions.
机构信息
Broad Institute of Harvard and MIT, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
出版信息
Angew Chem Int Ed Engl. 2011 Aug 22;50(35):8172-5. doi: 10.1002/anie.201103271. Epub 2011 Jul 12.
Abstract
Multicomponent Petasis reactions: the first diastereoselective Petasis reaction catalyzed by chiral biphenols that enables the synthesis of syn and anti β-amino alcohols in pure form has been developed. The reaction exploits a multicomponent approach that involves boronates, α-hydroxy aldehydes, and amines.
摘要
多组分 Petasis 反应：首次发展了手性联苯酚催化的非对映选择性 Petasis 反应，可实现纯形式的 syn 和 anti-β-氨基醇的合成。该反应利用了硼酸盐、α-羟基醛和胺的多组分方法。
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