Nerquaye-Tetteh J O, Clarke J R
J Reprod Fertil. 1987 Mar;79(2):575-9. doi: 10.1530/jrf.0.0790575.
Laboratory bred bank voles of different age and reproductive status were bilaterally ovariectomized, treated with exogenous oestrogen or progesterone or both, and given an artificial decidual stimulus (crushing with artery forceps). An hormonal regimen of oestrogen (100 ng) followed by progesterone (1 mg) and small amounts of oestrogen (10 ng) was necessary for maximal development of the decidual cell reaction (DCR). A DCR did not develop if the animals were treated with only oestrogen or progesterone. Middle-aged virgin females 5-7 months old had larger responses than did young virgin females 2-3 months old, and parous females, 15-19 months old and having had at least 10 litters, had a response similar to that of virgin females of about the same age. The size of the DCR in old parous females was inversely related to the time elapsing since the last litter. It is concluded that in its hormonal requirements for a successful DCR the bank vole is similar to the mouse. The results also suggest that the increase in fertility of bank voles up to the age of about 100 days may in part be explained by increased response of the endometrium to blastocysts. The reduction in size of the DCR in old animals is a consequence of ageing rather than of repeated pregnancies.
对不同年龄和生殖状态的实验室饲养的田鼠进行双侧卵巢切除，用外源性雌激素或孕酮或两者进行处理，并给予人工蜕膜刺激（用动脉钳挤压）。雌激素（100纳克）后接孕酮（1毫克）和少量雌激素（10纳克）的激素方案对于蜕膜细胞反应（DCR）的最大程度发展是必要的。如果动物仅用雌激素或孕酮处理，则不会发生DCR。5至7个月大的中年未孕雌性比2至3个月大的年轻未孕雌性反应更大，而15至19个月大且至少产过10窝的经产雌性的反应与大约相同年龄的未孕雌性相似。老龄经产雌性的DCR大小与自上次产仔后经过的时间呈负相关。得出的结论是，在成功的DCR的激素需求方面，田鼠与小鼠相似。结果还表明，田鼠在约100日龄前生育力的增加部分可能是由于子宫内膜对胚泡的反应增加。老龄动物中DCR大小的减小是衰老的结果，而不是反复怀孕的结果。
