Goodrick G J, Nelson J F
Department of Obstetrics and Gynecology, Center for the Study of Reproduction, McGill University.
J Gerontol. 1989 May;44(3):B67-71. doi: 10.1093/geronj/44.3.b67.
The effects of long-term ovariectomy (LOVX) and chronic food restriction on the decidual cell response were examined in aging mice. At 2 mos of age, mice were either ovariectomized, started on a regimen of food restriction (70% of ad lib intake), or left untreated. At 10 mos, the decidual cell response (DCR) was induced in all groups and measured by uterine weight gain, alkaline phosphatase activity, and DNA content. The DCR was also examined in young (4.5 mos) mice. LOVX and, to a lesser extent, food restriction (FR) potentiated the DCR, as indicated by 20-75% greater alkaline phosphatase activity and uterine weight relative to age-matched controls. In contrast to previous reports, however, there was no age-related reduction of the DCR. These results show that both LOVX and FR can enhance uterine function in middle-aged mice and indicate that, under some experimental conditions, there is no age-related impairment in the DCR.
在衰老小鼠中研究了长期卵巢切除术（LOVX）和慢性食物限制对蜕膜细胞反应的影响。2月龄时，将小鼠进行卵巢切除、开始食物限制方案（自由摄食量的70%）或不进行处理。10月龄时，在所有组中诱导蜕膜细胞反应（DCR），并通过子宫重量增加、碱性磷酸酶活性和DNA含量进行测量。还在年轻（4.5月龄）小鼠中检查了DCR。与年龄匹配的对照组相比，LOVX以及程度较轻的食物限制（FR）增强了DCR，碱性磷酸酶活性和子宫重量增加了20%-75%。然而，与先前的报道相反，DCR没有与年龄相关的降低。这些结果表明，LOVX和FR均可增强中年小鼠的子宫功能，并表明在某些实验条件下，DCR没有与年龄相关的损害。
