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Targeting O-GlcNAcylation in ischemic stroke.

作者信息

Li Xuan, Yang Wei

机构信息

Center for Perioperative Organ Protection, Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.

出版信息

Neural Regen Res. 2022 Nov;17(11):2427-2428. doi: 10.4103/1673-5374.335806.

DOI:10.4103/1673-5374.335806
PMID:35535885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9120690/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194c/9120690/aa0758eff7ef/NRR-17-2427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194c/9120690/aa0758eff7ef/NRR-17-2427-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/194c/9120690/aa0758eff7ef/NRR-17-2427-g001.jpg

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2
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O-GlcNAcylation Reduces Ischemia-Reperfusion-Induced Brain Injury.O-糖基化修饰可减轻缺血再灌注引起的脑损伤。
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Nat Metab. 2025 Aug 5. doi: 10.1038/s42255-025-01340-8.
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KDM2B regulates stroke injury by modulating OGT-mediated 0-GlcNAcylation of SLC7A11.KDM2B 通过调节 OGT 介导的 SLC7A11 的 0-GlcNAc 化来调节中风损伤。
Commun Biol. 2024 Nov 18;7(1):1530. doi: 10.1038/s42003-024-07251-w.
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O-GlcNAcylation in ischemic diseases.缺血性疾病中的O-连接N-乙酰葡糖胺化修饰

本文引用的文献

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Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice.XBP1s/O-GlcNAcylation 通路的激活可改善年轻和老年小鼠心脏骤停和复苏后的功能预后。
Shock. 2021 Nov 1;56(5):755-761. doi: 10.1097/SHK.0000000000001732.
2
Protein O-GlcNAcylation in the heart.心脏中的蛋白质 O-GlcNAc 修饰。
Acta Physiol (Oxf). 2021 Sep;233(1):e13696. doi: 10.1111/apha.13696. Epub 2021 Jun 17.
3
Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke.
Front Pharmacol. 2024 May 9;15:1377235. doi: 10.3389/fphar.2024.1377235. eCollection 2024.
4
Kaempferol regulates apoptosis and migration of neural stem cells to attenuate cerebral infarction by -GlcNAcylation of β-catenin.山奈酚通过β-连环蛋白的O-连接N-乙酰葡糖胺化调节神经干细胞的凋亡和迁移，以减轻脑梗死。
Open Life Sci. 2024 Mar 9;19(1):20220829. doi: 10.1515/biol-2022-0829. eCollection 2024.
5
Asialo-rhuEPO as a Potential Neuroprotectant for Ischemic Stroke Treatment.去唾液酸重组人促红细胞生成素作为缺血性中风治疗的潜在神经保护剂
Pharmaceuticals (Basel). 2023 Apr 18;16(4):610. doi: 10.3390/ph16040610.
缺血性脑卒中后，增加 O-GlcNAcylation 对年轻和老年大脑具有神经保护作用。
Exp Neurol. 2021 May;339:113646. doi: 10.1016/j.expneurol.2021.113646. Epub 2021 Feb 15.
4
Phase-specific manipulation of neuronal activity: a promising stroke therapy approach.神经元活动的阶段特异性调控：一种有前景的中风治疗方法。
Neural Regen Res. 2021 Jul;16(7):1425-1426. doi: 10.4103/1673-5374.301005.
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Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank.习惯性使用氨基葡萄糖与心血管疾病风险的关联：英国生物库的前瞻性研究。
BMJ. 2019 May 14;365:l1628. doi: 10.1136/bmj.l1628.
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Neurochem Int. 2019 Jul;127:87-93. doi: 10.1016/j.neuint.2018.12.018. Epub 2018 Dec 29.
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O-GlcNAcylation Reduces Ischemia-Reperfusion-Induced Brain Injury.O-糖基化修饰可减轻缺血再灌注引起的脑损伤。
Sci Rep. 2017 Sep 6;7(1):10686. doi: 10.1038/s41598-017-10635-0.
8
The emerging link between O-GlcNAcylation and neurological disorders.O-连接的N-乙酰葡糖胺糖基化（O-GlcNAcylation）与神经疾病之间新出现的联系。
Cell Mol Life Sci. 2017 Oct;74(20):3667-3686. doi: 10.1007/s00018-017-2542-9. Epub 2017 May 22.
9
XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.XBP1（X盒结合蛋白1）依赖性O-连接N-乙酰葡糖胺化对年轻小鼠缺血性中风具有神经保护作用，而老年小鼠中该作用的损伤可被噻美嗪-G挽救。
Stroke. 2017 Jun;48(6):1646-1654. doi: 10.1161/STROKEAHA.117.016579. Epub 2017 May 9.
10
Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling.硫胺素G通过调节小胶质细胞/巨噬细胞极化和抑制NF-κB p65信号传导介导实验性中风中的神经保护作用。
J Cereb Blood Flow Metab. 2017 Aug;37(8):2938-2951. doi: 10.1177/0271678X16679671. Epub 2016 Jan 1.