Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.
The National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China.
BMJ. 2019 May 14;365:l1628. doi: 10.1136/bmj.l1628.
To prospectively assess the association of habitual glucosamine use with risk of cardiovascular disease (CVD) events.
Prospective cohort study.
UK Biobank.
466 039 participants without CVD at baseline who completed a questionnaire on supplement use, which included glucosamine. These participants were enrolled from 2006 to 2010 and were followed up to 2016.
Incident CVD events, including CVD death, coronary heart disease, and stroke.
During a median follow-up of seven years, there were 10 204 incident CVD events, 3060 CVD deaths, 5745 coronary heart disease events, and 3263 stroke events. After adjustment for age, sex, body mass index, race, lifestyle factors, dietary intakes, drug use, and other supplement use, glucosamine use was associated with a significantly lower risk of total CVD events (hazard ratio 0.85, 95% confidence interval 0.80 to 0.90), CVD death (0.78, 0.70 to 0.87), coronary heart disease (0.82, 0.76 to 0.88), and stroke (0.91, 0.83 to 1.00).
Habitual use of glucosamine supplement to relieve osteoarthritis pain might also be related to lower risks of CVD events.
前瞻性评估习惯性使用氨基葡萄糖与心血管疾病（CVD）事件风险的相关性。
前瞻性队列研究。
英国生物库。
466039 名基线时无 CVD 的参与者完成了一份关于补充剂使用情况的问卷，其中包括氨基葡萄糖。这些参与者于 2006 年至 2010 年期间招募，并随访至 2016 年。
CVD 事件的发生，包括 CVD 死亡、冠心病和中风。
在中位数为 7 年的随访期间，共发生了 10204 例 CVD 事件、3060 例 CVD 死亡、5745 例冠心病事件和 3263 例中风事件。在调整年龄、性别、体重指数、种族、生活方式因素、饮食摄入、药物使用和其他补充剂使用后，氨基葡萄糖的使用与总 CVD 事件（风险比 0.85，95%置信区间 0.80 至 0.90）、CVD 死亡（0.78，0.70 至 0.87）、冠心病（0.82，0.76 至 0.88）和中风（0.91，0.83 至 1.00）的风险显著降低相关。
习惯性使用氨基葡萄糖补充剂缓解骨关节炎疼痛可能也与 CVD 事件风险降低有关。
