School of Nursing, Anhui Medical University, 15 Feicui Road, Hefei, 230032, Anhui, China.
Clin Rheumatol. 2022 Sep;41(9):2713-2720. doi: 10.1007/s10067-022-06195-y. Epub 2022 May 10.
To evaluate the reliability and validity of the Chinese version of the eight-item Morisky Medication Adherence Scale (MMAS-8) in Chinese patients with systemic lupus erythematosus (SLE).
The survey was conducted with a consecutive sampling of 158 Chinese SLE patients attending public hospitals from January to March 2021. We used the translated Chinese version of the MMAS-8 to collect related data. Reliability, item, and factor analyses were used to test the reliability and validity of the MMAS-8 scale in the selected patients. The internal consistency reliability was evaluated using Cronbach's α coefficient. Test-retest reliability was assessed using intraclass correlation coefficients (ICCs) in a subset of 30 participants. Construct validity was evaluated using confirmatory factor analysis and correlations between the Self-efficacy for Appropriate Medication Use Scale (SEAMS) and related measures.
The internal consistency reliability of the Chinese version of the MMAS-8 was high (Cronbach's α = 0.817), and the test-retest reliability was excellent (intraclass correlation = 0.947; P < 0.001). There were significant differences in the F test and t test between the two extreme groups before and after the ranking of 27% of the questionnaire scores (P < 0.001). The Kaiser-Meyer-Olkin (KMO) value of construct validity was 0.860. The spherical test value of Bartlettgers was 417.8822. Factor analysis yielded three components that accounted for 69.375% of the total variance. Exploratory factor analysis identified three dimensions of the Chinese version of the MMAS-8. In terms of criterion validity, the correlation of the MMAS-8 score in SEAMS indicated that the convergent validity was good (r = 0.926; P < 0.001).
This study shows that the Chinese version of the Medication Adherence Scale-8 is a reliable and valid tool for assessing medication adherence in Chinese SLE patients. Key Points • Many factors affect medication adherence in SLE patients. • Many questionnaires measure medication adherence levels. • There is a lack of reliable validation of medication adherence questionnaires specifically for SLE patients.
评估 Morisky 用药依从性量表 8 项中文版（MMAS-8）在中国系统性红斑狼疮（SLE）患者中的信度和效度。
本研究采用连续抽样法，于 2021 年 1 月至 3 月期间选取 158 例在公立医院就诊的中国 SLE 患者进行调查。采用翻译后的 MMAS-8 中文版收集相关数据。采用信度、项目和因子分析评估该量表在所选患者中的信度和效度。采用 Cronbach's α 系数评估内部一致性信度。在 30 名参与者中评估测试-再测试信度，采用组内相关系数（ICC）。采用验证性因子分析和与自我适当用药效能感量表（SEAMS）及相关测量的相关性评估结构效度。
中文版 MMAS-8 的内部一致性信度较高（Cronbach's α=0.817），测试-再测试信度极好（ICC=0.947；P<0.001）。在对问卷评分前 27%的排序进行极端分组后，F 检验和 t 检验差异有统计学意义（P<0.001）。结构效度的 Kaiser-Meyer-Olkin（KMO）值为 0.860。球形 Bartlettgers 检验值为 417.8822。因子分析得出三个组成部分，占总方差的 69.375%。探索性因子分析确定了中文版 MMAS-8 的三个维度。在效标效度方面，SEAMS 中 MMAS-8 评分的相关性表明，其收敛效度良好（r=0.926；P<0.001）。
本研究表明，中文版 MMAS-8 是评估中国 SLE 患者药物依从性的可靠、有效的工具。
关键点
· 许多因素会影响 SLE 患者的药物依从性。
· 有许多问卷可用于衡量药物依从性水平。
· 针对 SLE 患者的药物依从性问卷缺乏可靠的验证。
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