Targeting 5-HT as a Potential Treatment for Social Deficits in Autism.
作者信息
Yang Guangyi, Geng Hongyan, Hu Chun
机构信息
Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, South China Normal University, Guangzhou, 510631, China.
Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, 510631, China.
出版信息
Neurosci Bull. 2022 Oct;38(10):1263-1266. doi: 10.1007/s12264-022-00876-z. Epub 2022 May 10.
Abstract
摘要
相似文献
1
Targeting 5-HT as a Potential Treatment for Social Deficits in Autism.以5-羟色胺为靶点作为自闭症社交缺陷的潜在治疗方法。
Neurosci Bull. 2022 Oct;38(10):1263-1266. doi: 10.1007/s12264-022-00876-z. Epub 2022 May 10.
2
The brain serotonin system in autism.自闭症的大脑血清素系统。
Rev Neurosci. 2023 Jul 10;35(1):1-20. doi: 10.1515/revneuro-2023-0055. Print 2024 Jan 29.
3
5-HT release in nucleus accumbens rescues social deficits in mouse autism model.伏隔核中 5-HT 的释放可挽救自闭症模型小鼠的社交缺陷。
Nature. 2018 Aug;560(7720):589-594. doi: 10.1038/s41586-018-0416-4. Epub 2018 Aug 8.
4
Relationship between autistic traits and social functioning in healthy individuals.自闭症特质与健康个体社会功能的关系。
Neuropsychopharmacol Rep. 2022 Jun;42(2):226-229. doi: 10.1002/npr2.12249. Epub 2022 Apr 1.
5
How is quantification of social deficits useful for studying autism and schizophrenia?社交缺陷的量化对于研究自闭症和精神分裂症有何用处？
Psychol Med. 2020 Feb;50(3):523-525. doi: 10.1017/S0033291719003180. Epub 2019 Nov 22.
6
Critical roles of serotonin-oxytocin interaction during the neonatal period in social behavior in 15q dup mice with autistic traits.15q 重复自闭症小鼠幼年期 5-羟色胺-催产素相互作用对社会行为的关键作用。
Sci Rep. 2018 Sep 12;8(1):13675. doi: 10.1038/s41598-018-32042-9.
7
Modeling early cortical serotonergic deficits in autism.模拟自闭症早期皮质血清素能缺陷
Behav Brain Res. 2007 Jan 10;176(1):94-108. doi: 10.1016/j.bbr.2006.08.026. Epub 2006 Oct 10.
8
Effects of oxytocin on serotonin 1B agonist-induced autism-like behavior in mice.催产素对血清素1B激动剂诱导的小鼠自闭症样行为的影响。
Behav Brain Res. 2016 Nov 1;314:52-64. doi: 10.1016/j.bbr.2016.07.027. Epub 2016 Jul 18.
9
Serotonergic circuit dysregulation underlying autism-related phenotypes in BTBR mouse model of autism.自闭症 BTBR 小鼠模型中与自闭症相关表型的血清素能回路失调。
Neuropharmacology. 2023 Oct 1;237:109634. doi: 10.1016/j.neuropharm.2023.109634. Epub 2023 Jun 9.
10
Probiotics and prebiotics alleviate behavioral deficits, inflammatory response, and gut dysbiosis in prenatal VPA-induced rodent model of autism.益生菌和益生元可缓解自闭症产前 VPA 诱导的啮齿动物模型的行为缺陷、炎症反应和肠道菌群失调。
Physiol Behav. 2022 Nov 1;256:113961. doi: 10.1016/j.physbeh.2022.113961. Epub 2022 Sep 11.
引用本文的文献
1
Targeting 5-HT to Alleviate Dose-Limiting Neurotoxicity in Nab-Paclitaxel-Based Chemotherapy.靶向5-羟色胺以减轻基于纳米白蛋白结合型紫杉醇化疗的剂量限制性神经毒性
Neurosci Bull. 2025 May 14. doi: 10.1007/s12264-025-01398-0.
2
Serotonin: A Bridge for Infant-mother Bonding.血清素：母婴联结的桥梁。
Neurosci Bull. 2023 Nov;39(11):1741-1744. doi: 10.1007/s12264-023-01117-7. Epub 2023 Sep 16.
3
Impact of the circadian nuclear receptor REV-ERBα in dorsal raphe 5-HT neurons on social interaction behavior, especially social preference.生物钟核受体 REV-ERBα 在中缝背核 5-HT 神经元中对社会互动行为的影响，特别是对社会偏好的影响。
Exp Mol Med. 2023 Aug;55(8):1806-1819. doi: 10.1038/s12276-023-01052-7. Epub 2023 Aug 3.
4
Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys.猴大脑全脑和细胞特异性转录组学对 MRI 衍生皮质形态的研究
Nat Commun. 2023 Mar 17;14(1):1499. doi: 10.1038/s41467-023-37246-w.
本文引用的文献
1
Neurexins in serotonergic neurons regulate neuronal survival, serotonin transmission, and complex mouse behaviors.血清素能神经元中的神经连接蛋白调节神经元存活、血清素传递和复杂的小鼠行为。
Elife. 2023 Jan 25;12:e85058. doi: 10.7554/eLife.85058.
2
5-HT modulation of a medial septal circuit tunes social memory stability.5-羟色胺调节隔内侧核回路调节社会记忆稳定性。
Nature. 2021 Nov;599(7883):96-101. doi: 10.1038/s41586-021-03956-8. Epub 2021 Oct 6.
3
Systemic enhancement of serotonin signaling reverses social deficits in multiple mouse models for ASD.系统增强血清素信号可逆转多种 ASD 小鼠模型的社交缺陷。
Neuropsychopharmacology. 2021 Oct;46(11):2000-2010. doi: 10.1038/s41386-021-01091-6. Epub 2021 Jul 8.
4
Projections from D2 Neurons in Different Subregions of Nucleus Accumbens Shell to Ventral Pallidum Play Distinct Roles in Reward and Aversion.伏隔核壳部不同亚区的 D2 神经元投射到腹侧苍白球在奖赏和厌恶中发挥不同作用。
Neurosci Bull. 2021 May;37(5):623-640. doi: 10.1007/s12264-021-00632-9. Epub 2021 Feb 6.
5
The neuroligins and the synaptic pathway in Autism Spectrum Disorder.自闭症谱系障碍中的神经连接蛋白与突触通路
Neurosci Biobehav Rev. 2020 Dec;119:37-51. doi: 10.1016/j.neubiorev.2020.09.017. Epub 2020 Sep 28.
6
Serotonin transporter availability in adults with autism-a positron emission tomography study.自闭症成人的血清素转运体可用性：一项正电子发射断层扫描研究。
Mol Psychiatry. 2021 May;26(5):1647-1658. doi: 10.1038/s41380-020-00868-3. Epub 2020 Aug 26.
7
Prevalence of Autism Spectrum Disorder in China: A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years.中国自闭症谱系障碍患病率的全国多中心基于人群的 6 至 12 岁儿童研究。
Neurosci Bull. 2020 Sep;36(9):961-971. doi: 10.1007/s12264-020-00530-6. Epub 2020 Jun 30.
8
Autism spectrum disorder: definition, epidemiology, causes, and clinical evaluation.自闭症谱系障碍：定义、流行病学、病因及临床评估。
Transl Pediatr. 2020 Feb;9(Suppl 1):S55-S65. doi: 10.21037/tp.2019.09.09.
9
Serotonergic innervation of the amygdala is increased in autism spectrum disorder and decreased in Williams syndrome.杏仁核中的 5-羟色胺能神经支配在自闭症谱系障碍中增加，在威廉姆斯综合征中减少。
Mol Autism. 2020 Feb 5;11(1):12. doi: 10.1186/s13229-019-0302-4.
10
Neuroligins Differentially Mediate Subtype-Specific Synapse Formation in Pyramidal Neurons and Interneurons.神经连接蛋白在锥体神经元和中间神经元中差异调节特定亚型的突触形成。
Neurosci Bull. 2019 Jun;35(3):497-506. doi: 10.1007/s12264-019-00347-y. Epub 2019 Feb 21.
Zotero 插件