延伸因子调节黑皮质素饱食途径。
Elongator regulates the melanocortin satiety pathway.
机构信息
Department of Biological and Physical Sciences, Montana State University Billings, Billings, MT, 59101, USA; Pacific Northwest University of Health Sciences, Yakima, WA, 98901, USA.
Department of Biological and Physical Sciences, Montana State University Billings, Billings, MT, 59101, USA; UC Davis School of Medicine, Sacramento, CA, 59817, USA.
出版信息
Biochem Biophys Res Commun. 2022 Jul 12;613:73-80. doi: 10.1016/j.bbrc.2022.04.128. Epub 2022 May 2.
This study investigates the function of Elp1 and Elongator in the pituitary gland. Two conditional knockout models were generated where Elp1 was selectively deleted in either somatotropes of the anterior pituitary or Pomc-expressing cells of the anterior and intermediate pituitary. Although loss of Elp1 in somatotropes did not significantly impact murine growth or development, its loss in Pomc-expressing cells resulted in dramatically reduced levels of α-MSH, hyperphagia and obesity. This report provides the first evidence that Elongator plays an essential role in regulating the melanocortin satiety pathway.
本研究调查了 Elp1 和 Elongator 在垂体中的功能。我们生成了两种条件性敲除模型，其中 Elp1 在前垂体的生长激素细胞或前和中垂体的 Pomc 表达细胞中被选择性地删除。虽然 Elp1 在生长激素细胞中的缺失并未显著影响小鼠的生长或发育，但在 Pomc 表达细胞中的缺失导致 α-MSH、过度摄食和肥胖的水平显著降低。本报告首次提供了证据表明，Elongator 在调节黑皮质素食欲通路中起着至关重要的作用。
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