Eisenhut Larina, Sadeghi-Bahmani Dena, Gerber Markus, Saemann Attill, Staub Laurin, Brand Serge, Cordier Dominik
University of Basel, Department of Neurosurgery, Basel, Switzerland; University of Basel, Department of Sport, Exercise and Health, Division of Sport Science and Psychosocial Health, Basel, Switzerland; Center for Affective, Stress and Sleep Disorders (ZASS), Psychiatric University Hospital Basel, 4002, Basel, Switzerland.
Department of Psychology, Stanford University, Stanford, CA, USA.
J Psychiatr Res. 2022 Jul;151:354-364. doi: 10.1016/j.jpsychires.2022.03.058. Epub 2022 May 3.
There is evidence that regular exercise training has the potential to improve psychological well-being among cancer survivors. However, limited findings are available for individuals with high-grade glioma (HGG; WHO grade III and IV) after neurosurgery and undergoing radiochemotherapy. Given this, endurance and strengths training were employed to investigate their impact on symptoms of depression, feelings of stress and anxiety, fatigue, insomnia, and physical fitness, compared to an active control condition.
A total of 29 patients (M = 52.07, SD = 12.45, 55.2% women) participated in this randomized controlled trial (RCT). After neurosurgical treatment and during adjuvant radiotherapy and chemotherapy or combined radiochemotherapy, patients were randomly assigned to the following conditions: Endurance training (n = 10); strengths training (n = 11); active control condition (n = 8). At baseline, three weeks and six weeks later at the end of the study physical fitness was objectively measured with a 6-min walk test (6MWT) and a handgrip test. Participants completed a series of questionnaires covering sociodemographic information, symptoms of depression, stress, anxiety, fatigue, and insomnia. Further, experts rated participants' severity of symptoms of depression.
Over time and compared to the strengths and active control condition, self-rated symptoms of depression, state and trait anxiety, stress and insomnia decreased in the endurance condition. Over time and compared to the endurance and active control condition, no changes on symptoms of depression, anxiety, stress, or insomnia were observed in the strengths condition. Over time and compared to the endurance and strengths condition, symptoms of depression (self-ratings), stress, insomnia and fatigue decreased in the active control condition. Fatigue increased in both exercising conditions. Over time and irrespective from the study condition, physical fitness did neither improve nor decrease.
The pattern of results suggests that endurance training and an active control condition improved dimensions of depression, stress, and anxiety, while mere strengths training appeared to neither improve, nor decrease dimensions of psychological functioning. Further, exercise interventions did not change physical fitness, but increased fatigue. Overall, endurance training and an active control condition appeared to favorably impact on psychological well-being among patients with high-grade glioma after neurosurgery and undergoing radiochemotherapy.
有证据表明，定期运动训练有可能改善癌症幸存者的心理健康。然而，对于神经外科手术后接受放化疗的高级别胶质瘤（HGG；世界卫生组织III级和IV级）患者，相关研究结果有限。鉴于此，本研究采用耐力训练和力量训练，与积极对照条件相比，调查它们对抑郁症状、压力感、焦虑、疲劳、失眠和身体素质的影响。
共有29名患者（M = 52.07，SD = 12.45，55.2%为女性）参与了这项随机对照试验（RCT）。在神经外科治疗后以及辅助放疗和化疗或联合放化疗期间，患者被随机分配到以下组：耐力训练组（n = 10）；力量训练组（n = 11）；积极对照组（n = 8）。在基线、研究结束时的三周和六周后，通过6分钟步行试验（6MWT）和握力试验客观测量身体素质。参与者完成了一系列问卷，涵盖社会人口学信息、抑郁、压力、焦虑、疲劳和失眠症状。此外，专家对参与者的抑郁症状严重程度进行了评估。
随着时间推移，与力量训练组和积极对照组相比，耐力训练组的自我评定抑郁症状、状态焦虑和特质焦虑、压力和失眠症状有所减轻。随着时间推移，与耐力训练组和积极对照组相比，力量训练组的抑郁、焦虑、压力或失眠症状没有变化。随着时间推移，与耐力训练组和力量训练组相比，积极对照组的抑郁症状（自我评定）、压力、失眠和疲劳症状有所减轻。两种运动训练组的疲劳感均增加。随着时间推移，无论研究条件如何，身体素质既没有改善也没有下降。
结果模式表明，耐力训练和积极对照条件改善了抑郁、压力和焦虑维度，而单纯的力量训练似乎既没有改善也没有降低心理功能维度。此外，运动干预没有改变身体素质，但增加了疲劳感。总体而言，耐力训练和积极对照条件似乎对神经外科手术后接受放化疗的高级别胶质瘤患者的心理健康有积极影响。
