Department of Neurosurgery, University Hospital Basel, 4031, Basel, Switzerland.
Division of Sport and Psychosocial Health, Department of Sport, Exercise and Health, University of Basel, 4052, Basel, Switzerland.
Cancer Commun (Lond). 2019 Aug 9;39(1):46. doi: 10.1186/s40880-019-0390-8.
There is existing evidence on whether and to what degree regular exercise training improves the quality of life (QoL) among cancer survivors. However, in regards to patients with high-grade glioma (HGG; WHO grade III and IV), no conclusive study has been performed so far. The present trial aims to fill this gap by examining whether psychological well-being, sleep, QoL and physical fitness might be improved with two different types of exercise, as compared to an active control condition. Active control condition represent individuals participating at regular meetings to talk about their current life situation, though, the meetings were not intended as that of the psychotherapy group. Regular meetings are of the same frequency, duration, and intensity as the exercise interventions.
A total of 45 patients with HGG after undergoing neurosurgery and adjuvant radiotherapy, chemotherapy, or chemoradiotherapy will be consecutively and randomly assigned to (a) an endurance training, (b) a resistance training or (c) to an active control condition. The intervention will last for 6 consecutive weeks, consisting of 2 weekly sessions (30-45 min per session). Measurements would take place at three time points, namely at the beginning of the study (baseline), 3 weeks after the beginning of the study, and 6 weeks after the beginning of the study. The last measurement also represents the end of the study. Aerobic exercise performance will be assessed objectively with a 6-min walking test, and a handgrip test will be used to assess the upper body strength. Further, participants will complete a battery of questionnaires covering sociodemographic information, QoL, sleep quality and sleep patterns, coping with stress, state- and trait-anxiety, depression, and fatigue. In parallel, experts will use the Hamilton Depression Rating Scale to determine and rate participants' symptoms of depression.
The present study will be the first to investigate and compare the impact of two different exercise modalities, namely endurance and resistance training, on physical fitness and dimensions of well-being, and sleep among patients with HGG who underwent neurosurgery followed by adjuvant radiotherapy, chemotherapy, or chemoradiotherapy. Importantly, unlike the majority of previous studies, the control condition consists of an active set-up to detect possible factual beneficial effects of exercise training, irrespective of social interactions. Trial registration https://register.clinicaltrials.gov ; identifier: NCT03775369.
目前已有证据表明，规律的运动训练是否以及在何种程度上可以提高癌症幸存者的生活质量（QoL）。然而，对于高级别胶质瘤（HGG；WHO 分级 III 和 IV）患者，目前尚无定论。本试验旨在通过比较两种不同类型的运动与积极对照组相比，是否可以改善心理幸福感、睡眠、QoL 和身体适应性，以填补这一空白。积极对照组代表参加定期会议以讨论当前生活状况的个体，但会议并不像心理治疗组那样。定期会议的频率、持续时间和强度与运动干预相同。
共有 45 名接受神经外科手术以及辅助放疗、化疗或放化疗的 HGG 患者将连续随机分配至（a）耐力训练组、（b）阻力训练组或（c）积极对照组。干预将持续 6 周，每周进行 2 次（每次 30-45 分钟）。测量将在三个时间点进行，即研究开始时（基线）、研究开始后 3 周和研究开始后 6 周。最后一次测量也代表研究结束。有氧运动能力将通过 6 分钟步行测试进行客观评估，握力测试用于评估上肢力量。此外，参与者将完成一系列问卷，涵盖社会人口学信息、QoL、睡眠质量和模式、应对压力、状态和特质焦虑、抑郁和疲劳。同时，专家将使用汉密尔顿抑郁评定量表确定并评估参与者的抑郁症状。
本研究将首次调查和比较两种不同运动方式（即耐力和阻力训练）对接受神经外科手术及辅助放疗、化疗或放化疗后的 HGG 患者身体适应性和幸福感维度以及睡眠的影响。重要的是，与大多数先前的研究不同，对照组采用积极的设置来检测运动训练的可能实际有益效果，而不考虑社会互动。试验注册：https://register.clinicaltrials.gov；标识符：NCT03775369。
