眶额皮层负责时间顺序的工作记忆。
Orbitofrontal cortex governs working memory for temporal order.
机构信息
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Departments of Medical Social Sciences and Pediatrics, Northwestern University, Chicago, IL 60611, USA.
Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
出版信息
Curr Biol. 2022 May 9;32(9):R410-R411. doi: 10.1016/j.cub.2022.03.074.
How do we think about time? Converging lesion and neuroimaging evidence indicates that orbitofrontal cortex (OFC) supports the encoding and retrieval of temporal context in long-term memory, which may contribute to confabulation in individuals with OFC damage. Here, we reveal that OFC damage diminishes working memory for temporal order, that is, the ability to disentangle the relative recency of events as they unfold. OFC lesions reduced working memory for temporal order but not spatial position, and individual deficits were commensurate with lesion size. Comparable effects were absent in patients with lesions restricted to lateral prefrontal cortex (PFC). Based on these findings, we propose that OFC supports understanding of the order of events. Well-documented behavioral changes in individuals with OFC damage may relate to impaired temporal-order understanding.
我们如何思考时间？集中病变和神经影像学证据表明，眶额皮层（OFC）支持长期记忆中时间背景的编码和检索，这可能有助于解释 OFC 损伤患者的虚构。在这里，我们揭示了 OFC 损伤会降低时间顺序的工作记忆，即随着事件展开而区分事件相对新近度的能力。OFC 损伤减少了对时间顺序的工作记忆，但不影响空间位置，并且个体缺陷与损伤大小成正比。在仅限于外侧前额叶皮层（PFC）的患者中，没有类似的影响。基于这些发现，我们提出 OFC 支持对事件顺序的理解。OFC 损伤患者的行为变化有据可查，可能与时间顺序理解受损有关。
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