University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA.
University of Chicago Medicine Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA.
Cancer Cell. 2022 May 9;40(5):452-454. doi: 10.1016/j.ccell.2022.04.008.
In this issue of Cancer Cell, Anadon et al. perform a multi-omics analysis of ovarian tumor infiltrating tissue-resident memory T (TRM) cells at the single-cell level that supports a differentiation model from CD103TCF1 re-circulating T-cell precursors driven by tumor antigen recognition. CD103 TRM cells play a dominant anti-tumor role in ovarian cancer.
在本期《癌细胞》杂志中，Anadon 等人对卵巢肿瘤浸润组织驻留记忆 T（TRM）细胞进行了单细胞水平的多组学分析，该分析支持了一种分化模型，即肿瘤抗原识别驱动 CD103TCF1 再循环 T 细胞前体分化为 CD103 TRM 细胞。CD103 TRM 细胞在卵巢癌中发挥着主导的抗肿瘤作用。
