Molecular Biology Unit, Sirius Training and Research Centre, Khartoum, Sudan.
Health Emergencies and Epidemics Control General Directorate, Sudan Federal Ministry of Health, Khartoum, Sudan.
Trans R Soc Trop Med Hyg. 2022 Sep 10;116(9):763-766. doi: 10.1093/trstmh/trac041.
A cholera outbreak in Blue Nile and Sennar states, south-eastern and southern Sudan, took place during September-December 2019. An outbreak surveillance sample collection was made. Vibrio cholerae O1 Ogawa was isolated from clinical samples of all confirmed 200 and 132 cases in Blue Nile state and Sennar state, respectively. The case fatality rate was higher in Blue Nile state, 4% compared with only 2.3% in Sennar state. The Euvichol-Plus oral cholera vaccine was rapidly deployed for the first time in Sudan to the most at-risk populations in the two affected states, 1 471 188 and 1 546 542 individuals in Sennar and Blue Nile states, respectively. The rapid deployment of cholera vaccines as the major prevention and control strategy was successful and helped greatly with the containment of this epidemic. In-depth genomics studies are crucial for understanding the disease dynamics in Sudan by identifying locally circulating strains of the bacteria and further improving prevention and control strategy by characterising the susceptibility and resistance of these locally circulating strains to currently used antibiotics.
2019 年 9 月至 12 月，苏丹东南部和南部的青尼罗河州和森纳尔州暴发霍乱疫情。开展了疫情监测样本采集工作。从青尼罗河州和森纳尔州所有确诊的 200 例和 132 例病例的临床样本中分离出了霍乱弧菌 O1 型 Ogawa 血清群。青尼罗河州的病死率较高，为 4%，而森纳尔州仅为 2.3%。首次在苏丹迅速向两个受灾州风险最高的人群（森纳尔州 1 471 188 人，青尼罗河州 1 546 542 人）部署了 Euvichol-Plus 口服霍乱疫苗。将霍乱疫苗迅速用作主要的预防和控制策略是成功的，这极大地有助于控制此次疫情。通过鉴定当地流行的细菌菌株，开展深入的基因组学研究对于了解苏丹的疾病动态至关重要，进一步通过描述这些当地流行的菌株对目前使用的抗生素的敏感性和耐药性，改进预防和控制策略。
