Pulmonology Clinic, Hospital Otávio de Freitas, Rua Aprígio Guimarães s/n, Pernambuco, Tejipió, Recife, Brazil.
Laboratório Do Sono E Coração, Pronto Socorro Cardiológico de Pernambuco, (PROCAPE) da Universidade de Pernambuco, Rua dos Palmares, s/n, Santo Amaro, Recife, Brazil.
Sleep Breath. 2023 May;27(2):765-770. doi: 10.1007/s11325-022-02635-w. Epub 2022 May 11.
To evaluate arterial stiffness, a predictor of vascular damage was assessed by means of pulse wave velocity (PWV) in patients with chronic obstructive pulmonary disease (COPD) and comorbid obstructive sleep apnea (OSA), namely overlap syndrome (OS).
Consecutive stable patients with COPD were evaluated for OSA by means of overnight polysomnography in the laboratory. A clinical assessment was performed according to a strict protocol, including two COPD questionnaires: the COPD assessment test and the modified Medical Research Council scale. COPD severity was graded according to the guidelines of the Global Initiative for Chronic Obstructive Lung Disease. Arterial stiffness was assessed by means of PWV, using a standard technique.
Of 102 patients with COPD, 51 had associated OSA. The OS group had more men than the COPD group (73% vs. 47%, respectively; p < 0.01). Both groups had similar ages (66.2 ± 9.2 years vs. 69.6 ± 10.7, p = 0.09) and airflow limitation (p = 0.37). Hypertension was found in 22% of COPD patients, as opposed to 17% patients in the OS group (p = 0.29). High PWV values were present in 42% of the patients. Patients with COPD and OS had the same PWV values (9.8 vs. 10.5 m/s, p = 0.34). There were no differences in central blood pressure, peripheral blood pressure, and augmentation index between the two groups (p > 0.05).
High PWV values were frequently observed in patients with COPD. However, there was no difference in PWV between patients with OS and those with COPD alone.
评估慢性阻塞性肺疾病（COPD）合并阻塞性睡眠呼吸暂停（OSA）患者（重叠综合征，OS）的血管损伤预测因子——动脉僵硬度，采用脉搏波速度（PWV）进行评估。
连续评估稳定期 COPD 患者的 OSA，在实验室进行过夜多导睡眠图检查。按照严格的方案进行临床评估，包括两个 COPD 问卷：COPD 评估测试和改良的医学研究委员会量表。根据全球慢性阻塞性肺疾病倡议的指南对 COPD 严重程度进行分级。采用标准技术通过 PWV 评估动脉僵硬度。
在 102 例 COPD 患者中，51 例合并 OSA。OS 组的男性多于 COPD 组（分别为 73%和 47%；p<0.01）。两组的年龄（66.2±9.2 岁比 69.6±10.7 岁；p=0.09）和气流受限（p=0.37）相似。高血压在 COPD 患者中占 22%，而在 OS 组中占 17%（p=0.29）。42%的患者存在高 PWV 值。COPD 和 OS 患者的 PWV 值相同（9.8 比 10.5 m/s；p=0.34）。两组间中心血压、外周血压和增强指数无差异（p>0.05）。
COPD 患者常出现高 PWV 值。然而，OS 患者和单纯 COPD 患者的 PWV 值没有差异。
