Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, 13115, Jordan.
Department of Pharmaceutical Technology, School of Pharmacy, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
AAPS PharmSciTech. 2022 May 10;23(5):140. doi: 10.1208/s12249-022-02293-x.
Aqueous colloidal dispersions of water-insoluble polymers (APDs) avoid hassles associated with the use of organic solvents and offer processing advantages related to their low viscosity and short processing times. Therefore, they became the main vehicle for pharmaceutical coating of tablets and multiparticulates, a process commonly employed using pan and fluidized-bed machinery. Another interesting although less common processing approach is co-spray drying APDs with drugs in aqueous systems. It enables the manufacture of capsule- and matrix-type microspheres with controllable size and improved processing characteristics in a single step. These microspheres can be further formulated into different dosage forms. This systematic review is based on published research articles and aims to highlight the applicability and opportunities of co-spray drying drugs with APDs in drug delivery.
水不溶性聚合物的水胶体分散体（APD）避免了与使用有机溶剂相关的麻烦，并提供了与其低粘度和短加工时间相关的加工优势。因此，它们成为片剂和多颗粒药物包衣的主要载体，该过程通常使用盘式和流化床机械进行。另一种有趣但不太常见的加工方法是在水系统中将 APD 与药物共喷雾干燥。它能够在一步中制造具有可控尺寸和改进加工特性的胶囊型和基质型微球。这些微球可以进一步配制成不同的剂型。本系统评价基于已发表的研究文章，旨在强调药物与 APD 共喷雾干燥在药物传递中的适用性和机会。
