Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Police General Hospital, Bangkok, Thailand.
BMC Pediatr. 2022 May 10;22(1):258. doi: 10.1186/s12887-022-03325-y.
Anogenital distance (AGD) is a marker of prenatal androgen exposure and a tool for assessment of differences of sex development. Data for AGD in newborns have been published, but these findings may not be applicable to Thai newborns.
To provide the sex-specific ranges for AGD in Thai full-term newborns.
A cross-sectional study was conducted in term newborns in Thailand, during 2016-2018. AGD was measured from anus to anterior base of penis (AGD) and to perineoscrotal junction (AGD) in males and from anus to clitoris (AGD) and to posterior fourchette (AGD) in females. AGD ratio is defined as AGD divided by AGD in males and AGD divided by AGD in females.
A total of 364 newborns were studied (male 51.4%). The mean AGD, AGD and AGD ratio in males were 25.20 ± 4.80, 52.60 ± 6.90 and 0.48 ± 0.08 mm, respectively. The mean AGD, AGD, and AGD ratio in females were 16.50 ± 3.90, 42.60 ± 6.20 and 0.39 ± 0.08 mm, respectively. There were significant differences between AGD and AGD, AGD and AGD, and AGD ratio between males and females (p < 0.001). The AGD, AGD, AGD, AGD were correlated with birth weight and length, but AGD ratio showed no correlation.
The sex-specific ranges for AGD in Thai full-term newborns were determined. AGD ratio is a useful marker of prenatal androgen exposure since it differs between sexes, but constant between races and did not vary by body size.
肛门生殖器距离（AGD）是产前雄激素暴露的标志物，也是评估性别发育差异的工具。已经发表了关于新生儿 AGD 的数据，但这些发现可能不适用于泰国新生儿。
提供泰国足月新生儿 AGD 的性别特异性范围。
本研究为泰国的一项横断面研究，于 2016-2018 年期间纳入足月新生儿。在男性中，AGD 从肛门测量到阴茎前基部（AGD）和会阴阴囊交界处（AGD），在女性中，AGD 从肛门测量到阴蒂（AGD）和后阴唇分叉处（AGD）。AGD 比定义为 AGD 除以男性的 AGD 和 AGD 除以女性的 AGD。
共研究了 364 名新生儿（男性占 51.4%）。男性的平均 AGD、AGD 和 AGD 比分别为 25.20±4.80、52.60±6.90 和 0.48±0.08mm。女性的平均 AGD、AGD 和 AGD 比分别为 16.50±3.90、42.60±6.20 和 0.39±0.08mm。男性和女性之间的 AGD 和 AGD、AGD 和 AGD 以及 AGD 比均存在显著差异（p<0.001）。AGD、AGD、AGD 与出生体重和身长相关，但 AGD 比与两者均不相关。
确定了泰国足月新生儿的 AGD 性别特异性范围。AGD 比是产前雄激素暴露的有用标志物，因为它在性别之间存在差异，但在种族之间保持不变，且不受体型大小的影响。
