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尼日利亚流行的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）毒株的系统发育和全基因组突变分析：对减轻的2019冠状病毒病（COVID-19）结果无影响。

Phylogenetic and genome-wide mutational analysis of SARS-CoV-2 strains circulating in Nigeria: no implications for attenuated COVID-19 outcomes.

作者信息

Kolawole Daniel B, Okeke Malachy I

机构信息

Department of Natural and Environmental Sciences, Biomedical Science Concentration, School of Arts and Sciences, American University of Nigeria, Yola, Nigeria.

出版信息

Osong Public Health Res Perspect. 2022 Apr;13(2):101-113. doi: 10.24171/j.phrp.2021.0329. Epub 2022 Apr 22.

DOI:10.24171/j.phrp.2021.0329
PMID:35538682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9091640/
Abstract

OBJECTIVES

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). The COVID-19 incidence and mortality rates are low in Nigeria compared to global trends. This research mapped the evolution of SARS-CoV-2 circulating in Nigeria and globally to determine whether the Nigerian isolates are genetically distinct from strains circulating in regions of the world with a high disease burden.

METHODS

Bayesian phylogenetics using BEAST 2.0, genetic similarity analyses, and genomewide mutational analyses were used to characterize the strains of SARS-CoV-2 isolated in Nigeria.

RESULTS

SARS-CoV-2 strains isolated in Nigeria showed multiple lineages and possible introductions from Europe and Asia. Phylogenetic clustering and sequence similarity analyses demonstrated that Nigerian isolates were not genetically distinct from strains isolated in other parts of the globe. Mutational analysis demonstrated that the D614G mutation in the spike protein, the P323L mutation in open reading frame 1b (and more specifically in NSP12), and the R203K/ G204R mutation pair in the nucleocapsid protein were most prevalent in the Nigerian isolates.

CONCLUSION

The SARS-CoV-2 strains in Nigeria were neither phylogenetically nor genetically distinct from virus strains circulating in other countries of the world. Thus, differences in SARS-CoV-2 genomes are not a plausible explanation for the attenuated COVID-19 outcomes in Nigeria.

摘要

目的

严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是2019冠状病毒病（COVID-19）的病原体。与全球趋势相比，尼日利亚的COVID-19发病率和死亡率较低。本研究绘制了在尼日利亚和全球范围内传播的SARS-CoV-2的进化图谱，以确定尼日利亚分离株在基因上是否与世界上疾病负担高的地区传播的毒株不同。

方法

使用BEAST 2.0进行贝叶斯系统发育分析、遗传相似性分析和全基因组突变分析来表征在尼日利亚分离的SARS-CoV-2毒株。

结果

在尼日利亚分离出的SARS-CoV-2毒株显示出多个谱系，并可能来自欧洲和亚洲。系统发育聚类和序列相似性分析表明，尼日利亚分离株在基因上与全球其他地区分离出的毒株没有区别。突变分析表明，刺突蛋白中的D614G突变、开放阅读框1b（更具体地说是NSP12）中的P323L突变以及核衣壳蛋白中的R203K/G204R突变对在尼日利亚分离株中最为普遍。

结论

尼日利亚的SARS-CoV-2毒株在系统发育和基因上均与世界其他国家传播的病毒毒株没有区别。因此，SARS-CoV-2基因组的差异并非尼日利亚COVID-19结果减弱的合理原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/9091640/2a144bb56d9d/j-phrp-2021-0329f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/9091640/dd49dc3b7938/j-phrp-2021-0329f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/9091640/ccd7e4a6e47c/j-phrp-2021-0329f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/9091640/1ff727d73909/j-phrp-2021-0329f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/9091640/2a144bb56d9d/j-phrp-2021-0329f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/9091640/dd49dc3b7938/j-phrp-2021-0329f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/9091640/ccd7e4a6e47c/j-phrp-2021-0329f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/9091640/1ff727d73909/j-phrp-2021-0329f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f892/9091640/2a144bb56d9d/j-phrp-2021-0329f4.jpg

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Cell Host Microbe. 2021 Dec 8;29(12):1788-1801.e6. doi: 10.1016/j.chom.2021.11.005. Epub 2021 Nov 13.
2
Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective.新冠疫情一年期间严重急性呼吸综合征冠状病毒2的遗传多样性：全球视角
Biomedicines. 2021 Apr 11;9(4):412. doi: 10.3390/biomedicines9040412.
3
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity.
多种 SARS-CoV-2 变异株逃避疫苗诱导的体液免疫中和作用。
Cell. 2021 Apr 29;184(9):2372-2383.e9. doi: 10.1016/j.cell.2021.03.013. Epub 2021 Mar 12.
4
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5
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