Department of Pediatrics, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
J Pediatr Endocrinol Metab. 2022 May 12;35(6):813-817. doi: 10.1515/jpem-2022-0144. Print 2022 Jun 27.
Glycemic control is an important parameter that can predict long-term complications of diabetes mellitus. It can be affected by many factors. Hence, identifying those factors for improving disease outcomes is essential. The purpose of this study was to assess glycemic control in children who were treated with a conventional insulin regimen and to identify its associated factors.
A retrospective cohort study was conducted among children with type one diabetes mellitus (T1DM) who had follow-up from November 2015 to November 2020 at the pediatric endocrinology clinic of St. Paul's Hospital Millennium Medical College in Addis Ababa, Ethiopia. Glycemic control was assessed by measuring glycosylated hemoglobin (HbA) and children who had HbA within three to six months of the data collection were recruited.
A total of 106 children with TIDM who were on conventional insulin therapy were included in this study. Their median age at diagnosis was nine years, 47.2% were females, and 57.5% were from urban areas. The average HbA of the children was 9.7%. The majority (85.2%) of the children had poor glycemic control (>7.5%). Younger age, longer disease duration, and urban residence were found to be significant predictors of good glycemic control.
A significant majority of children with T1DM had poor glycemic control. This calls for the need to create access to intensive diabetes care by health authorities and stakeholders to prevent the long-term complications of T1DM.
血糖控制是预测糖尿病长期并发症的一个重要参数，它受到许多因素的影响。因此，确定这些因素以改善疾病结局至关重要。本研究旨在评估接受常规胰岛素治疗的儿童的血糖控制情况，并确定其相关因素。
这是一项在埃塞俄比亚亚的斯亚贝巴圣保罗医院千年医学学院儿科内分泌科接受随访的 1 型糖尿病（T1DM）儿童中进行的回顾性队列研究。通过测量糖化血红蛋白（HbA）来评估血糖控制情况，并且在数据收集的三个月至六个月内 HbA 处于正常范围内的儿童被纳入研究。
本研究共纳入 106 名接受常规胰岛素治疗的 TIDM 儿童。他们的诊断年龄中位数为 9 岁，47.2%为女性，57.5%来自城市地区。儿童的平均 HbA 为 9.7%。大多数（85.2%）儿童的血糖控制不佳（>7.5%）。研究发现，年龄较小、疾病持续时间较长和居住在城市是血糖控制良好的显著预测因素。
绝大多数 T1DM 儿童的血糖控制不佳。这需要卫生当局和利益相关者创造机会，提供强化的糖尿病护理，以预防 T1DM 的长期并发症。
