Zhang Qian, Song Wei, Liang Xiao-Chun
Department of Traditional Chinese Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Medical Research Center,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2022 Apr;44(2):313-317. doi: 10.3881/j.issn.1000-503X.13040.
Diabetic neuropathy is a common diabetic complication.The application of metabolomics in the research on diabetic neuropathy is beneficial for us to understand the pathophysiological processes and overall metabolic disturbance of the nervous system under the condition of hyperglycemia,decipher the pathogenesis of diabetic neuropathy,and mine the potential biomarkers for clinical diagnosis and treatment.Long-term hyperglycemia may lead to disorders in multiple pathways,such as tricarboxylic acid circle,amino acid metabolism,and lipid metabolism.These metabolic changes are closely associated with the injuries of the peripheral and central nervous system.In the paper,we reviewed the metabolomics-based studies about diabetic neuropathy in the last five years.
糖尿病神经病变是一种常见的糖尿病并发症。代谢组学在糖尿病神经病变研究中的应用有助于我们了解高血糖状态下神经系统的病理生理过程和整体代谢紊乱，阐明糖尿病神经病变的发病机制，并挖掘临床诊断和治疗的潜在生物标志物。长期高血糖可能导致多种代谢途径紊乱，如三羧酸循环、氨基酸代谢和脂质代谢。这些代谢变化与外周和中枢神经系统损伤密切相关。在本文中，我们综述了过去五年基于代谢组学的糖尿病神经病变研究。
