左乙拉西坦与苯妥英钠治疗小儿癫痫持续状态的安全性和有效性比较：一项荟萃分析。
Comparison of Safety and Effectiveness between Levetiracetam and Phenytoin in the Treatment of Pediatric Status Epilepticus: A Meta- Analysis.
机构信息
Emergency Medicine Resident, King Fahad University Hospital, Al Khobar 34445, Saudi Arabia.
Department of Pediatric, Maternity and Children Hospital Hassa, Dammam 32253, Saudi Arabia.
出版信息
CNS Neurol Disord Drug Targets. 2023;22(5):745-751. doi: 10.2174/1568007X04666220509215121.
OBJECTIVE
To evaluate the safety and effectiveness of levetiracetam and phenytoin by evaluating the events of seizure termination and recurrence in children.
METHODS
We used the internet databases PubMed, Embase, and Google Scholar to conduct a literature search for the appropriate studies. A meta-analysis was performed to calculate the odds ratio using fixed and random-effects models.
RESULTS
We identified 15 studies that were eligible for the meta-analysis. The incidence of seizure termination within 24 h was 76.9% for levetiracetam and 70.5% for phenytoin. Levetiracetam had a higher number of seizure termination events than phenytoin (P = 0.005, I = 66%). The incidence of seizure recurrence within 24 h was 10% for levetiracetam and 15.6% for phenytoin. Phenytoin had a significantly higher number of seizure recurrence events than levetiracetam (P = 0.00007, I = 21%).
CONCLUSION
The efficacy and safety of levetiracetam are superior to that of phenytoin in children with status epilepticus. Large Randomized Controlled Trial studies are needed to confirm the result in children.
目的
通过评估癫痫发作终止和复发事件，评估左乙拉西坦和苯妥英的安全性和有效性。
方法
我们使用互联网数据库 PubMed、Embase 和 Google Scholar 对合适的研究进行文献检索。使用固定效应模型和随机效应模型计算比值比进行荟萃分析。
结果
我们确定了 15 项符合荟萃分析条件的研究。左乙拉西坦在 24 小时内终止癫痫发作的发生率为 76.9%，苯妥英为 70.5%。左乙拉西坦的癫痫发作终止事件数量多于苯妥英（P = 0.005，I = 66%）。左乙拉西坦在 24 小时内癫痫复发的发生率为 10%，苯妥英为 15.6%。苯妥英的癫痫复发事件数量明显多于左乙拉西坦（P = 0.00007，I = 21%）。
结论
左乙拉西坦治疗儿童癫痫持续状态的疗效和安全性优于苯妥英。需要进行大型随机对照试验研究来证实这一结果在儿童中的应用。
Zotero 插件