Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, 256197Wollo University, Dessie, Ethiopia.
Department of Medical Laboratory Sciences, 608018Dessie Health Science College, Dessie, Ethiopia.
Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221097379. doi: 10.1177/10760296221097379.
Thrombocytopenia is a common hematological abnormality during gestation. Pregnant women with severe thrombocytopenia may be associated with a higher risk of excessive bleeding during or after delivery. Therefore, the main aim of this study was to assess the magnitude and associated factors of thrombocytopenia among pregnant women attending antenatal care services at Dessie comprehensive and specialized hospital, Northeast Ethiopia.
An institution-based cross-sectional study was conducted from February to March 2021. Using a systematic random sampling technique, a total of 294 pregnant women were enrolled in the study. Structured interviewer-administered questionnaires were used to collect socio-demographic and clinical data of study participants. Four ml of venous blood were collected from each pregnant woman and a complete blood count was determined using DIRUI BF 6500 automated hematology analyzer. Data were entered into Epidata version 4.6.0 and then exported into SPSS version 24.0. Multivariate logistic regression was used to assess the association between dependent and independent variables. P-value < 0.05 was considered to be statistically significant.
A total of 294 pregnant women who visited antenatal care services at Dessie comprehensive specialized hospital were included. The mean (±SD) age of the study participants was 29.7 (±6.1) years. The prevalence of thrombocytopenia among pregnant women was 9.9% (95% CI: 6.5, 13.6). A mild type of thrombocytopenia is the major type and accounted for 72.4% whereas moderate thrombocytopenia and severe thrombocytopenia accounted for 17.2% and 10.4% respectively among pregnant women. Multivariate logistic regression showed that urban residents (AOR: 0.206,95% CI, 0.055-0.748), gestational ages within the first trimester (AOR: 0.183, 95% CI, 0.057-0.593) and gestational ages within the second trimester (AOR = 0.264, 95% CI, 0.092-0.752) were significantly associated and independent predictors of thrombocytopenia in pregnant women.
In this study, the prevalence of thrombocytopenia was 9.9% and the mild type of thrombocytopenia (72.4%) was higher than the other type of thrombocytopenia among pregnant women. In multivariate logistic regression analysis, residence and gestational age (trimester) were significantly associated with thrombocytopenia. Therefore, the platelet count should be routinely determined during the antenatal care visit for proper diagnosis and to minimize bleeding during and or after childbirth.
血小板减少症是妊娠期常见的血液学异常。严重血小板减少症的孕妇在分娩期间或之后可能会有过度出血的更高风险。因此，本研究的主要目的是评估在埃塞俄比亚东北部德西综合和专科医院接受产前保健服务的孕妇中血小板减少症的程度和相关因素。
这是一项 2021 年 2 月至 3 月进行的基于机构的横断面研究。使用系统随机抽样技术，共纳入 294 名孕妇。使用结构式访谈员管理的问卷收集研究参与者的社会人口学和临床数据。从每位孕妇采集 4ml 静脉血，使用 DIRUI BF 6500 自动化血液分析仪测定全血细胞计数。数据录入 Epidata 版本 4.6.0，然后导出到 SPSS 版本 24.0。采用多变量逻辑回归评估因变量和自变量之间的关联。P 值<0.05 被认为具有统计学意义。
共纳入 294 名在德西综合专科医院接受产前保健服务的孕妇。研究参与者的平均（±SD）年龄为 29.7（±6.1）岁。孕妇血小板减少症的患病率为 9.9%（95%CI：6.5，13.6）。轻度血小板减少症是主要类型，占 72.4%，而中度血小板减少症和重度血小板减少症分别占 17.2%和 10.4%。多变量逻辑回归显示，城市居民（AOR：0.206，95%CI：0.055-0.748）、孕早期（AOR：0.183，95%CI：0.057-0.593）和孕中期（AOR=0.264，95%CI：0.092-0.752）与孕妇血小板减少症显著相关且独立预测因素。
在这项研究中，血小板减少症的患病率为 9.9%，孕妇中轻度血小板减少症（72.4%）高于其他类型的血小板减少症。在多变量逻辑回归分析中，居住地和孕龄（孕周期）与血小板减少症显著相关。因此，应在产前保健就诊时常规测定血小板计数，以进行适当诊断并最大程度减少分娩期间或之后的出血。
