Synthesis, optical, electrochemical properties and anticancer activity of (S)-BINOL cored triazole bridged dendrimers decorated with rhodamine B surface group.

(S)-BINOL cored dendrimers 1-3 with a rhodamine B surface group and triazole bridging unit were synthesized up to second generation in good yield by convergent synthesis through click chemistry. The chiro-optical property of the synthesized dendrimers reveals that the specific rotation increases as the order of dendrimer increases from the zeroth generation to the second generation dendrimer. The electrochemical properties of the dendrimers 1, 2 and 3 showed quasi-reversible behavior in cyclic voltammetry. The anticancer activity against human hepatocellular carcinoma cell for the second generation dendrimer 3 was found to be better than that for the lower generation dendrimers 1 and 2.