Chen Xiaofang, Tan Jianyang, Zhang Lu, Liu Yonggang, Cheng Yahong, Zhang Qianying, Ding Hong
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan University Wuhan 430071 Hubei P. R. China
RSC Adv. 2018 Jul 6;8(43):24470-24476. doi: 10.1039/c8ra04459g. eCollection 2018 Jul 2.
The abuse of fructose in daily diet may cause cardiovascular diseases that seriously threaten human health, and both safe and efficient solutions need to be developed. We investigated whether apigenin can prevent the harmful impact of excessive fructose on cardiovascular events. Based on the reduction of percentage of body fat and systolic pressure as well as the improvements in insulin resistance, lipid metabolism, and pathological injury to the thoracic aorta, we suggested that high levels of fructose cause vascular injury and metabolic disorders, which can be improved to some extent by using apigenin. Fundamentally, apigenin down-regulates levels of phosphoinositide 3-kinase (PI3K), protein kinase B (AKT), and glucose transporter 1 (GLUT1), which increase with high concentrations of fructose. Moreover, the inflammation and asymmetric dimethylarginine (ADMA) levels increased in fructose group, but they decreased when the rats were fed with apigenin. The results suggest that PI3K/AKT/GLUT1 may have potential for alleviating cardiovascular injury, and apigenin can be an excellent candidate for supplements to ameliorate cardiovascular diseases related to high fructose consumption.
日常饮食中果糖的滥用可能会引发严重威胁人类健康的心血管疾病，因此需要开发安全有效的解决方案。我们研究了芹菜素是否能够预防过量果糖对心血管事件产生的有害影响。基于体脂百分比和收缩压的降低以及胰岛素抵抗、脂质代谢的改善和胸主动脉病理损伤的减轻，我们认为高剂量果糖会导致血管损伤和代谢紊乱，而使用芹菜素可以在一定程度上改善这些情况。从根本上来说，芹菜素会下调磷脂酰肌醇3激酶（PI3K）、蛋白激酶B（AKT）和葡萄糖转运蛋白1（GLUT1）的水平，而这些物质的水平会随着高浓度果糖而升高。此外，果糖组的炎症和不对称二甲基精氨酸（ADMA）水平升高，但在给大鼠喂食芹菜素后则有所降低。结果表明，PI3K/AKT/GLUT1可能具有减轻心血管损伤的潜力，并且芹菜素可能是改善与高果糖摄入相关的心血管疾病的优质补充剂候选物。
