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无催化剂和无溶剂法合成2-芳基喹啉：2-甲基喹啉与二炔酮的[5 + 1]环化反应

Catalyst- and solvent-free approach to 2-arylated quinolines [5 + 1] annulation of 2-methylquinolines with diynones.

作者信息

Zhao Hai-Yuan, Wu Fu-Song, Yang Li, Liang Ying, Cao Xiao-Lin, Wang Heng-Shan, Pan Ying-Ming

机构信息

School of Life and Environmental Sciences, Guilin University of Electronic Technology Guilin 541004 China

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University Guilin 541004 China

出版信息

RSC Adv. 2018 Jan 25;8(9):4584-4587. doi: 10.1039/c7ra12716b. eCollection 2018 Jan 24.

DOI:10.1039/c7ra12716b
PMID:35539512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9077778/
Abstract

A novel route for the synthesis of 2-arylated quinolines through a [5 + 1] annulation directly from 2-methylquinolines and diynones under catalyst-free and solvent-free conditions was disclosed. This synthetic process was atom-economic, with good tolerance of a broad range of functional groups, and with great practical worth.

摘要

公开了一种在无催化剂和无溶剂条件下，直接由2-甲基喹啉和二炔酮通过[5 + 1]环化反应合成2-芳基喹啉的新途径。该合成过程具有原子经济性，对多种官能团具有良好的耐受性，具有很高的实用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc7/9077778/3546b95f695b/c7ra12716b-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc7/9077778/2988816e69ff/c7ra12716b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc7/9077778/d0a6aaa8c8b6/c7ra12716b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc7/9077778/6c50977bfe17/c7ra12716b-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc7/9077778/3546b95f695b/c7ra12716b-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc7/9077778/2988816e69ff/c7ra12716b-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc7/9077778/d0a6aaa8c8b6/c7ra12716b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc7/9077778/6c50977bfe17/c7ra12716b-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bc7/9077778/3546b95f695b/c7ra12716b-s3.jpg

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