Univ. Grenoble Alpes, DPM UMR 5063, F-38041 Grenoble, France.
Nat Prod Rep. 2016 Sep 25;33(9):1034-43. doi: 10.1039/c6np00039h. Epub 2016 Jun 27.
Covering up to 2016Nauclea latifolia (syn. Sarcocephalus latifolius, Rubiaceae), commonly called the African pincushion tree, is a plant widely used in folk medicine in different regions of Africa for treating a variety of illnesses, including malaria, epilepsy and pain. N. latifolia has not only drawn the interest of traditional healers but also of phytochemists, who have identified a range of bioactive indole alkaloids in its tissue. More recently, following up on the traditional use of extracts in pain management, a bio-guided purification from the roots of the tree led to the identification of the active ingredient as tramadol, available as a synthetic analgesic since the 1970s. The discovery of this compound as a natural phytochemical was highlighted worldwide. This review focuses on the correlation between extracted compounds and pharmacological activities, paying special attention to infectious diseases and neurologically-related disorders. A critical analysis of the data reported so far on the natural origin of tramadol and its proposed biosynthesis is also presented.
覆盖到 2016 年，鸡骨常山（别名：宽叶鸡骨常山，茜草科），通常被称为非洲大头针树，是一种在非洲不同地区的民间医学中广泛用于治疗各种疾病的植物，包括疟疾、癫痫和疼痛。鸡骨常山不仅引起了传统治疗师的兴趣，也引起了植物化学家的兴趣，他们在其组织中鉴定出了一系列生物活性吲哚生物碱。最近，在对提取物在疼痛管理中的传统用途进行研究后，从树的根部进行生物导向的纯化导致鉴定出活性成分曲马多，自 20 世纪 70 年代以来，它作为一种合成镇痛药。这一化合物作为天然植物化学物质的发现引起了全世界的关注。这篇综述重点关注了提取化合物与药理活性之间的相关性，特别关注了传染病和与神经系统相关的疾病。还对迄今为止关于曲马多天然来源及其提出的生物合成的报告数据进行了批判性分析。
