多种取代的双吡咯里西啶/硫代吡咯里西啶氧化吲哚/苊并姜黄素类化合物的合成——顺序甲亚胺叶立德环加成反应

Synthesis of diversely substituted bis-pyrrolizidino/ thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids sequential azomethine ylide cycloaddition.

作者信息

Singh Meenakshi, Hazra Abhijit, Bharitkar Yogesh P, Kalia Ritu, Sahoo Ashutosh, Saha Sneha, Ravichandiran V, Ghosh Shekhar, Mondal Nirup B

机构信息

National Institute of Pharmaceutical Education and Research (NIPER) (IICB Campus), 4, Raja S. C. Mullick Road, Jadavpur Kolkata - 700 032 India.

Department of Organic and Medicinal Chemistry, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research 4, Raja S. C. Mullick Road, Jadavpur Kolkata - 700 032 India

出版信息

RSC Adv. 2018 May 23;8(34):18938-18951. doi: 10.1039/c8ra02725k. eCollection 2018 May 22.

Curcumin has been transformed to several diversely substituted bis-pyrrolizidino/thiopyrrolizidino oxindolo/acenaphthyleno curcuminoids a sequential azomethine ylide cycloaddition reaction using isatins/acenaphthoquinone and proline/thioproline as the reagents. The products were separated extensive chromatography and characterized by 1D/2D NMR and HRMS analysis.