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木平原A-F，六种来自……的新愈创木烷型倍半萜二聚体。 （注：原文中“from”后面缺少具体来源信息）

Xyloplains A-F, six new guaiane-type sesquiterpenoid dimers from .

作者信息

Xie Yang-Guo, Zhang Weiyue, Zhu Sheng-Lan, Cheng Tao-Fang, Wu Guo-Jing, Muhammad Ishaq, Yan Shi-Kai, Zhang Yan, Jin Hui-Zi, Zhang Wei-Dong

机构信息

School of Pharmacy, Shanghai Jiao Tong University Shanghai 200240 P. R. China

School of Pharmacy, Second Military Medical University Shanghai 200433 P. R. China.

出版信息

RSC Adv. 2018 Jul 18;8(45):25719-25724. doi: 10.1039/c8ra04356f. eCollection 2018 Jul 16.

DOI:10.1039/c8ra04356f
PMID:35539790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9082531/
Abstract

Six new guaiane dimers, xyloplains A-F (1-6), with connecting patterns through two direct C-C bonds (C-1 to C-3', C-2 to C-1'), were isolated from the roots of . Their structures were elucidated clearly using extensive analysis of 1D NMR and 2D NMR, combined with Cu-Kα X-ray diffraction and circular dichroism (CD) experiments. In additon, all of the isolates were tested for anti-inflammatory activity by measuring the amount of nitric oxide produced. To our delight, compounds 2 and 6 exhibited moderate inhibitory activity against the production of nitric oxide with IC value of 34.5 and 31.1 μM, respectively, in RAW264.7 cells stimulated by LPS.

摘要

从[植物名称]的根部分离出六个新的愈创木烷二聚体，即木平原A - F（1 - 6），它们通过两个直接的C - C键（C - 1至C - 3'，C - 2至C - 1'）连接。通过对一维核磁共振（1D NMR）和二维核磁共振（2D NMR）进行广泛分析，并结合Cu - Kα X射线衍射和圆二色性（CD）实验，明确阐明了它们的结构。此外，通过测量一氧化氮的产生量对所有分离物进行了抗炎活性测试。令我们高兴的是，在脂多糖（LPS）刺激的RAW264.7细胞中，化合物2和6对一氧化氮的产生表现出中等抑制活性，IC值分别为34.5和31.1 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/f1f2c330f68e/c8ra04356f-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/861433751df4/c8ra04356f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/fe2ab45a2f1e/c8ra04356f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/8a57e370fd86/c8ra04356f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/e94beb15ed16/c8ra04356f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/6f65fc1c7cb4/c8ra04356f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/a563aa43a99d/c8ra04356f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/9589ffcd4d2b/c8ra04356f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/2e1dcc9c6210/c8ra04356f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/f1f2c330f68e/c8ra04356f-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/861433751df4/c8ra04356f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/fe2ab45a2f1e/c8ra04356f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/8a57e370fd86/c8ra04356f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/e94beb15ed16/c8ra04356f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/6f65fc1c7cb4/c8ra04356f-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/a563aa43a99d/c8ra04356f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/9589ffcd4d2b/c8ra04356f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/2e1dcc9c6210/c8ra04356f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bbc0/9082531/f1f2c330f68e/c8ra04356f-f9.jpg

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本文引用的文献

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Biomed Pharmacother. 2017 Dec;96:30-36. doi: 10.1016/j.biopha.2017.09.116. Epub 2017 Nov 24.
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Xylopiana A, a Dimeric Guaiane with a Case-Shaped Core from Xylopia vielana: Structural Elucidation and Biomimetic Conversion.西萝藦 A，来自维腊木 Xylopia vielana 的具有箱型核心的二聚大牻牛儿烷：结构阐明和仿生转化。
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Licocoumarone isolated from Glycyrrhiza uralensis selectively alters LPS-induced inflammatory responses in RAW 264.7 macrophages.
从甘草中分离出的光甘草定可选择性改变脂多糖诱导的RAW 264.7巨噬细胞炎症反应。
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Guaiane dimers from Xylopia vielana.来自维耶拉木瓣树的愈创木烷二聚体。
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