Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Org Lett. 2017 Jun 2;19(11):3013-3016. doi: 10.1021/acs.orglett.7b01276. Epub 2017 May 24.
Xylopiana A (1), a dimeric guaiane with an unprecedented pentacyclo[5.2.1.0.0.0]decane-3,2'-dione core, and three biosynthetically related intermediates, compounds 2-4, were isolated from the leaves of Xylopia vielana. Their structures and absolute configurations were determined by a combination of spectroscopic data, X-ray crystallography, electronic circular dichroism calculations, and chemical conversion. The structure of known vielanin A was revised to be compound 3. Compound 4 exerted a 3.7-fold potentiation effect on doxorubicin susceptibility at the tested concentration of 10 μM.
从 Xylopia vielana 的叶子中分离得到了一个具有前所未有的五环[5.2.1.0.0.0]癸烷-3,2'-二酮核心的二聚倍半萜 Xylopiana A（1）和三个生物合成相关的中间体化合物 2-4。通过光谱数据、X 射线晶体学、电子圆二色性计算和化学转化的组合，确定了它们的结构和绝对构型。已知 vielanin A 的结构被修订为化合物 3。化合物 4 在测试浓度为 10 μM 时对阿霉素敏感性的增强作用达到 3.7 倍。
