使用KF/穴状配体-222配合物在制备规模上进行无过渡金属、后期、区域特异性的芳香族氟化反应。
Transition metal free, late-stage, regiospecific, aromatic fluorination on a preparative scale using a KF/crypt-222 complex.
作者信息
Jakobsson Jimmy Erik, Riss Patrick Johannes
机构信息
Realomics Strategic Research Initiative, Department of Chemistry, Faculty for Mathematics and Natural Sciences, University of Oslo Norway
Department of Surgery and Neuroscience, OUS-Rikshospitalet HF Oslo Norway.
出版信息
RSC Adv. 2018 Jun 11;8(38):21288-21291. doi: 10.1039/c8ra03757d. eCollection 2018 Jun 8.
We herein report the development of a convenient, regioselective, aromatic fluorination method of hypervalent iodonium ylides for synthesising fluoro-arenes on a preparative scale. This transition metal free, nucleophilic methodology provides good yields for sterically hindered substrates, irrespective of activation. The methodology simplifies reference synthesis for PET imaging.
我们在此报告了一种便捷、区域选择性的高价碘叶立德芳香氟化方法的开发，用于在制备规模上合成氟代芳烃。这种无过渡金属的亲核方法对于空间位阻较大的底物能提供良好的产率，且无需活化。该方法简化了用于正电子发射断层扫描（PET）成像的参考合成。
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