特定药物对暴露于2,3,7,8-四氯二苯并-对-二噁英（TCDD）的雌性大鼠骨骼的调节作用。

Modulating effect of selected pharmaceuticals on bone in female rats exposed to 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD).

作者信息

Dobrzynski Maciej, Pezowicz Celina, Tomanik Magdalena, Kuropka Piotr, Dudek Krzysztof, Fita Katarzyna, Styczynska Marzena, Wiglusz Rafal J

机构信息

Department of Conservative Dentistry and Pedodontics, The Faculty of Dentistry, Wroclaw Medical University Poland

Department of Biomedical Engineering, Mechatronics and Theory of Mechanisms, Faculty of Mechanical Engineering, Wroclaw University of Science and Technology Poland.

出版信息

RSC Adv. 2018 Aug 2;8(48):27537-27545. doi: 10.1039/c8ra03619e. eCollection 2018 Jul 30.

This paper discusses the problems connected with the influence of TCDD on the mechanical properties and structure of the bone tissue in female rats treated with the dioxin. Moreover an analysis of the protective role of tocopherol, acetylsalicylic acid, dexamethazone and levamisol was performed. Rat tibiae were assessed by mechanical testing, and histological and trace element analysis. It was proved that TCDD has negative effect on bone mechanical properties, histological microstructure and trace element content. The results indicate that usage of both steroid and non-steroid anti-inflammatory medicaments, along with tocopherol and levamisol, modulating their activity, can reduce the negative effect of dioxin activity on the bone tissue of female rats intoxicated with TCDD.