Fallon J H, Moore R Y
J Comp Neurol. 1978 Aug 1;180(3):545-80. doi: 10.1002/cne.901800310.
In this study the location of dopamine (DA) neuron perikarya in the rostral mesencephalon of the rat was determined using the glyoxylic acid fluorescence histochemical technique. Subsequently the topography of the projection of these mesencephalic neurons on the basal forebrain and striatum was analyzed using the anterograde transport-autoradiographic tracing method and the retrograde transport-horseradish peroxidase (HRP) technique. The results of these anatomical studies were correlated with the biochemical and histochemical studies presented in previous reports (Moore, '78; Fallon and Moore, '78; Fallon et al., '78) to provide the following conclusions. The topography of the DA neuron projection of the basal forebrain and neostriatum is organized in three planes, dorsal-ventral, medial-lateral and anterior-posterior. DA cells are found almost exclusively in the substantia nigra (SN) and ventral tegmental area (VTA). Ventral cells of the SN and VTA project to the dorsal structures of the basal forebrain such as the septum, nucleus accumbens and neostriatum. The latter includes some DA cells located ventrally in the pars reticulata of the SN. Dorsal cells project to ventral structures. The medial-lateral topography is organized such that the medial sectors of the SN-VTA area project to the medial parts of nuclei in the basal forebrain and neostriatum whereas lateral sectors of the SN-VTA area project to the lateral parts of nuclei in the basal forebrain and neostriatum. An anterior-posterior topography also is evident such that anterior parts of the SN-VTA project anteriorly whereas the posterior SN-VTA projects more posteriorly in these areas. These observations are consistent with the view that the DA neurons of the SN-VTA complex form a single nuclear group with a highly topographically organized projection innervating not only deep nuclei of the telencephalon but allocortical structures as well.
在本研究中，运用乙醛酸荧光组织化学技术确定了大鼠中脑前部多巴胺（DA）神经元胞体的位置。随后，采用顺行运输-放射自显影追踪法和逆行运输-辣根过氧化物酶（HRP）技术，分析了这些中脑神经元在基底前脑和纹状体上的投射拓扑结构。这些解剖学研究结果与先前报告（Moore，1978年；Fallon和Moore，1978年；Fallon等人，1978年）中的生化和组织化学研究结果相关联，得出以下结论。基底前脑和新纹状体的DA神经元投射拓扑结构在背-腹、内-外和前-后三个平面上组织排列。DA细胞几乎仅存在于黑质（SN）和腹侧被盖区（VTA）。SN和VTA的腹侧细胞投射至基底前脑的背侧结构，如隔区、伏隔核和新纹状体。后者包括一些位于SN网状部腹侧的DA细胞。背侧细胞投射至腹侧结构。内-外拓扑结构的组织方式是，SN-VTA区域的内侧部分投射至基底前脑和新纹状体核团的内侧部分，而SN-VTA区域的外侧部分投射至基底前脑和新纹状体核团的外侧部分。前-后拓扑结构也很明显，即SN-VTA的前部向前投射，而SN-VTA的后部在这些区域向后投射更多。这些观察结果与以下观点一致，即SN-VTA复合体的DA神经元形成一个单核群，其投射具有高度的拓扑组织性，不仅支配端脑的深层核团，还支配异皮质结构。
