Kudo N, Yamada T
Neurosci Lett. 1987 Mar 20;75(1):43-8. doi: 10.1016/0304-3940(87)90072-3.
Bath-applied N-methyl-D,L-aspartate (NMA) was found to elicit locomotor electromyogram (EMG) activity in ankle flexor and extensor muscles in an in vitro lumbar cord-hindlimb preparation of the newborn rat. The frequency and burst duration of the NMA-induced rhythmic EMG activity varied in a dose-dependent manner. The locomotor activity was also observed in a mid sagittally split lumbar spinal preparation, in which the frequency was much lower. It is concluded that spinal neurones with N-methyl-D-aspartate (NMDA) receptors are involved in producing locomotor activity in the rat and that each spinal half can generate hindlimb locomotion on the ipsilateral side.
在新生大鼠的体外腰髓-后肢制备模型中，发现浴用N-甲基-D，L-天冬氨酸（NMA）可引发踝关节屈肌和伸肌的运动肌电图（EMG）活动。NMA诱导的节律性EMG活动的频率和爆发持续时间呈剂量依赖性变化。在矢状面中部切开的腰髓制备模型中也观察到了运动活动，但其频率要低得多。结论是，具有N-甲基-D-天冬氨酸（NMDA）受体的脊髓神经元参与了大鼠运动活动的产生，并且每个脊髓半侧都可以在同侧产生后肢运动。
