Ebrahimi Shamsi, Stephen Sipaut Coswald
Faculty of Engineering, Universiti Malaysia Sabah, UMS Road, Kota Kinabalu 88400, Sabah, Malaysia.
Nanomaterials (Basel). 2021 Sep 30;11(10):2576. doi: 10.3390/nano11102576.
Composite scaffolds of hydroxyapatite (HAp) nanoparticles and bioactive glass (BG) have been applied as appropriate materials for bone tissue engineering. In this study, hydroxyapatite/bioglass cement in different ratios was successfully fabricated. To prepare HAp and HAp/BG cement, synthesized HAp and HAp/BG powder were mixed in several ratios, using different concentrations of sodium hydrogen phosphate (SP) and water as the liquid phase. The liquid to powder ratio used was 0.4 mL/g. The results showed that setting time increased with BG content in the composite. The results also showed that with the addition of bioglass to the HAp structure, the density decreased and the porosity increased. It was also found that after immersion in simulated body fluid (SBF) solution, the compressive strength of the HAp and HAp/BG cements increased with BG concentration up to 30 wt.%. SEM results showed the formation of an apatite layer in all selected samples after immersion in SBF solution. At 30 wt.% BG, greater nucleation and growth of the apatite layer were observed, resulting in higher bioactivity than pure HAp and HAp/BG in other ratios.
羟基磷灰石（HAp）纳米颗粒与生物活性玻璃（BG）的复合支架已被用作骨组织工程的合适材料。在本研究中，成功制备了不同比例的羟基磷灰石/生物玻璃水泥。为制备HAp和HAp/BG水泥，将合成的HAp和HAp/BG粉末以几种比例混合，使用不同浓度的磷酸氢二钠（SP）和水作为液相。所用的液固比为0.4 mL/g。结果表明，凝固时间随复合材料中BG含量的增加而延长。结果还表明，在HAp结构中添加生物玻璃后，密度降低，孔隙率增加。还发现，在模拟体液（SBF）溶液中浸泡后，HAp和HAp/BG水泥的抗压强度随BG浓度增加而增加，直至30 wt.%。扫描电子显微镜（SEM）结果显示，在SBF溶液中浸泡后，所有选定样品中均形成了磷灰石层。在BG含量为30 wt.%时，观察到磷灰石层有更大的成核和生长，导致其生物活性高于其他比例的纯HAp和HAp/BG。
