阿片类药物与性行为。

Opioids and sexual behavior.

作者信息

Pfaus J G, Gorzalka B B

出版信息

Neurosci Biobehav Rev. 1987 Spring;11(1):1-34. doi: 10.1016/s0149-7634(87)80002-7.

Abstract

Opioids have long been known to inhibit sexual behavior. However, it is only within the last decade that the effects of opioids on sexual behavior have been studied extensively and a number of hormonal and neurochemical correlates established. In this review, the experimental literature on opioids and sexual behavior in humans and laboratory animals is examined. Clinical and anecdotal accounts of opioid use are also discussed, in addition to the pharmacology, neuroendocrinology, and biochemistry of opioid administration, to provide a synthesis of critical information. New research directions involving the study of endogenous opioid systems, opioid receptor subtypes, and the opioid modulation of neurotransmitter systems are outlined. Finally, a comprehensive bibliography of the human and animal literature is included.

摘要

长期以来，人们都知道阿片类药物会抑制性行为。然而，直到最近十年，阿片类药物对性行为的影响才得到广泛研究，并建立了一些激素和神经化学方面的关联。在这篇综述中，我们审视了关于人类和实验动物中阿片类药物与性行为的实验文献。除了阿片类药物给药的药理学、神经内分泌学和生物化学之外，还讨论了阿片类药物使用的临床和轶事记录，以综合关键信息。概述了涉及内源性阿片系统、阿片受体亚型以及神经递质系统的阿片类药物调节研究的新方向。最后，还收录了人类和动物文献的综合参考文献目录。