Franken N A, Van Langevelde A, Pauwels E K, Journée-de Korver J G, Bakker C N, Oosterhuis J A
Nucl Med Commun. 1986 Nov;7(11):797-809.
Radio-iodine-labelled thiouracil has been evaluated as a radiopharmaceutical for establishing the viability of ocular melanoma after radiation treatment. The uptake of 125I-5-iodo-2-thiouracil (125I-ITU) was studied in X-ray irradiated and non-irradiated melanotic melanomas implanted in Syrian golden hamsters. Uptake of 125I-ITU in melanomas 4 days after irradiation with 40 Gy X-ray was 25% of the value found in non-irradiated controls, 12 days after such treatment it was 10% of that value. Twenty-one days after radiation treatment the melanomas showed regrowth and uptake of 125I-ITU was about equal to that in non-treated controls. Uptake of 125I-ITU in melanomas after 10 Gy X-ray irradiation was higher and uptake in tumours after 20 Gy was only slightly lower than the uptake by non-irradiated melanomas. The results indicate that the iodine labelled-thiouracil uptake test may be useful as an additional diagnostic issue for assessing the viability of ocular melanoma after radiation therapy.
放射性碘标记的硫尿嘧啶已被评估为一种放射性药物，用于确定放射治疗后眼黑色素瘤的存活情况。研究了125I-5-碘-2-硫尿嘧啶（125I-ITU）在植入叙利亚金黄地鼠体内的经X射线照射和未经照射的黑色素性黑色素瘤中的摄取情况。用40 Gy X射线照射后4天，黑色素瘤对125I-ITU的摄取量为未照射对照组的25%，照射后12天，该摄取量为对照组的10%。放射治疗21天后，黑色素瘤出现再生，125I-ITU的摄取量与未治疗的对照组大致相同。10 Gy X射线照射后黑色素瘤对125I-ITU的摄取量较高，20 Gy照射后肿瘤的摄取量仅略低于未照射黑色素瘤的摄取量。结果表明，碘标记硫尿嘧啶摄取试验可能作为评估放射治疗后眼黑色素瘤存活情况的一项额外诊断指标。
