123I-5-碘-2-硫脲嘧啶（一种可能用于无创检测眼黑色素瘤的放射性药物）在仓鼠黑色素瘤和无黑色素黑色素瘤中的摄取情况。
Uptake of 123I-5-iodo-2-thiouracil, a possible radiopharmaceutical for noninvasive detection of ocular melanoma, in melanotic and amelanotic melanomas in hamsters.
作者信息
Franken N A, Van Langevelde A, Journée-De Korver J G, Bakker C N, Feitsma R I, Van Delft J L, Oosterhuis J A, Pauwels E K
出版信息
Nucl Med Commun. 1985 Oct;6(10):657-63. doi: 10.1097/00006231-198510000-00007.
The uptake of 123I-5-iodo-2-thiouracil in melanotic and amelanotic melanoma implanted in Syrian golden hamsters was studied. A selective accumulation was found in the tumours. Uptake of 123ITU in melanotic melanomas was 4 to 5 times the uptake in amelanotic ones. For both tumours high ratios of tumours versus non-tumour were found. The high accumulation of 123ITU in both kinds of tumours and the high tumour versus non-tumour ratios suggest that 123ITU may be a promising radiopharmaceutical for the detection of ocular melanoma.
研究了123I-5-碘-2-硫脲嘧啶在叙利亚金仓鼠体内植入的黑色素瘤和无黑色素黑色素瘤中的摄取情况。在肿瘤中发现有选择性蓄积。123ITU在黑色素瘤中的摄取量是无黑色素黑色素瘤中的4至5倍。两种肿瘤与非肿瘤组织的比值均较高。123ITU在两种肿瘤中的高蓄积以及高肿瘤与非肿瘤比值表明，123ITU可能是一种用于检测眼黑色素瘤的有前景的放射性药物。
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