Doita Susumu, Tamura Tomoki, Baba Takahiro, Oomori Hiroki, Nishii Kazuya, Nakanishi Masamoto, Kuyama Shoichi
Department of Respiratory Medicine, NHO Iwakuni Clinical Center, Iwakuni, Japan.
Respir Med Case Rep. 2022 Apr 25;37:101654. doi: 10.1016/j.rmcr.2022.101654. eCollection 2022.
Immunoglobulin G4 (IgG4)-related pleurisy is a rare type of IgG4-related disease. We present the case of a 69-year-old woman with left pleural effusion and elevated adenosine deaminase levels. Initially, tuberculous pleuritis was suspected; however, the bacterial cultures and polymerase chain reaction test results for tuberculosis were negative. Thoracoscopic pleural biopsy revealed dense lymphocytic infiltrates with large numbers of IgG4-positive plasma cells. The ratio of IgG4-positive to IgG-positive plasma cells exceeded 40%. The patient was diagnosed with IgG4-related disease.
免疫球蛋白G4（IgG4）相关性胸膜炎是一种罕见的IgG4相关疾病。我们报告一例69岁女性患者，有左侧胸腔积液且腺苷脱氨酶水平升高。最初怀疑为结核性胸膜炎；然而，结核的细菌培养和聚合酶链反应检测结果均为阴性。胸腔镜胸膜活检显示有密集的淋巴细胞浸润，伴有大量IgG4阳性浆细胞。IgG4阳性浆细胞与IgG阳性浆细胞的比例超过40%。该患者被诊断为IgG4相关疾病。
