三裂叶崖爬藤正己烷提取物对A2780细胞的化疗潜力。
Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells.
作者信息
Palanisamy Chella Perumal, Pethanan Sivakumar, Vincent Gopinath Gurulingam, Murugesan Karthigeyan, Ramachandran Ananthavalli, Sivanandam Ramu, Panagal Mani
机构信息
State Key Laboratory of Biobased Material and Green Papermaking, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China.
Department of zoology, M R Government arts college, Mannargudi, Tamil Nadu - 614001, India.
出版信息
Bioinformation. 2021 Aug 31;17(8):710-714. doi: 10.6026/97320630017710. eCollection 2021.
It is of interest to report the chemotherapeutic (drug target based) potential of n-hexane Cayratia trifolia L. (C.trifolia) extract on A2780 cell lines. mRNA and protein expression analysis of the human chemokine receptor (CXCR4) and human epidermal growth factor receptors-2 (HER2) were studied using RT-PCR analysis and western blot analysis. The results show significant cell growth inhibition with minimal IC50 values of 46.25 ± 0.42 micro g/mL against A2780 cell lines. mRNA and protein expression were considerably reduced in treated A2780 cell lines for further consideration as a chemotherapeutic agents.
报道正己烷三裂叶蛇葡萄（C.trifolia）提取物对A2780细胞系的化疗（基于药物靶点）潜力很有意义。使用逆转录聚合酶链反应（RT-PCR）分析和蛋白质印迹分析研究了人类趋化因子受体（CXCR4）和人类表皮生长因子受体-2（HER2）的信使核糖核酸（mRNA）和蛋白质表达。结果显示，对A2780细胞系具有显著的细胞生长抑制作用，半数抑制浓度（IC50）最小值为46.25±0.42微克/毫升。在经处理的A2780细胞系中，mRNA和蛋白质表达大幅降低，可进一步作为化疗药物进行研究。
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