Zhang Dawei, Liu Zhenzhen, Konetski Danielle, Wang Chen, Worrell Brady T, Bowman Christopher N
Department of Chemical and Biological Engineering, University of Colorado UCB 596 Boulder Colorado 80309 USA
Materials Science and Engineering Program, University of Colorado Boulder USA.
RSC Adv. 2018 Apr 18;8(26):14669-14675. doi: 10.1039/c8ra00247a. eCollection 2018 Apr 17.
Photocleavable liposomes were formed through the coupling of an -nitrobenzyl-containing azide tail precursor and an alkyne-functionalized lysolipid by the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. Inclusion of the photolabile -nitrobenzyl-structure enables control over the permeability and morphology of the liposomes. Photolysis of the -nitrobenzyl group changes the molecular structure of the photolabile phospholipids, inducing phase transitions and permeability increases in the bilayer membrane, ultimately disrupting the liposome entity.
通过铜催化的叠氮化物-炔烃环加成（CuAAC）反应，将含对硝基苄基的叠氮化物尾端前体与炔烃功能化溶血脂质偶联，形成了可光裂解脂质体。引入光不稳定的对硝基苄基结构能够控制脂质体的通透性和形态。对硝基苄基的光解改变了光不稳定磷脂的分子结构，诱导双层膜发生相变并增加通透性，最终破坏脂质体实体。
