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具有化疗和光热治疗药物持续释放特性的生理稳定F127-氧化石墨烯超分子水凝胶。

Physiologically stable F127-GO supramolecular hydrogel with sustained drug release characteristic for chemotherapy and photothermal therapy.

作者信息

Li Bingxia, Zhang Luna, Zhang Zichen, Gao Ruoqing, Li Hongmei, Dong Zhipeng, Wang Qiyan, Zhou Qingfa, Wang Yue

机构信息

Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University Nanjing 211198 Jiangsu Province China

State Key Laboratory of Coordination Chemistry, Nanjing University Nanjing 210093 Jiangsu Province China.

出版信息

RSC Adv. 2018 Jan 5;8(3):1693-1699. doi: 10.1039/c7ra12099k. eCollection 2018 Jan 2.

DOI:10.1039/c7ra12099k
PMID:35540894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9077132/
Abstract

A synthetic method for preparing a Pluronic F127 (F127)-stabilized graphene (GO) supramolecular hydrogel as a safe nanovehicle for combination treatment has been studied. Doxorubicin (DOX) as a model drug is non-covalently bound on the great surface area of GO due to strong π-π interaction, hydrophobic interaction, and the strongest hydrogen bonding. drug release experiments revealed that this F127-stabilized GO supramolecular hydrogel has a sustained drug release characteristic. Furthermore, the supramolecular hydrogel showed better antitumor ability under NIR (near infrared) laser irradiation because of the excellent photothermal effect of GO. Moreover, we evaluated its antitumor ability and the results show that the hydrogel system can also markedly inhibit the growth of a tumor when administered individually, especially under laser irradiation. All these findings make the supramolecular hydrogel system promising for combination therapy with good bioavailability and minimal side effects.

摘要

研究了一种制备泊洛沙姆F127（F127）稳定的氧化石墨烯（GO）超分子水凝胶的合成方法，该水凝胶作为一种安全的纳米载体用于联合治疗。作为模型药物的阿霉素（DOX）由于强烈的π-π相互作用、疏水相互作用和最强的氢键作用，非共价结合在GO的大表面积上。药物释放实验表明，这种F127稳定的GO超分子水凝胶具有持续药物释放特性。此外，由于GO具有优异的光热效应，该超分子水凝胶在近红外（NIR）激光照射下显示出更好的抗肿瘤能力。此外，我们评估了其抗肿瘤能力，结果表明，该水凝胶系统单独给药时也能显著抑制肿瘤生长，尤其是在激光照射下。所有这些发现使得该超分子水凝胶系统有望用于联合治疗，具有良好的生物利用度和最小的副作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/f6b5c6824db0/c7ra12099k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/947cf1d48acc/c7ra12099k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/3e6751ce4baf/c7ra12099k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/780972df0546/c7ra12099k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/3cbd4998482c/c7ra12099k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/eb30ba833fa5/c7ra12099k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/80cb94204b54/c7ra12099k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/f6b5c6824db0/c7ra12099k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/947cf1d48acc/c7ra12099k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/3e6751ce4baf/c7ra12099k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/780972df0546/c7ra12099k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/3cbd4998482c/c7ra12099k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/eb30ba833fa5/c7ra12099k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/80cb94204b54/c7ra12099k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0df/9077132/f6b5c6824db0/c7ra12099k-f6.jpg

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[5]
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[6]
Synthesis, Characterization, and Toxicity Assessment of Pluronic F127-Functionalized Graphene Oxide on the Embryonic Development of Zebrafish (.

Int J Nanomedicine. 2020-10-28

本文引用的文献

[1]
Porphyrin Immobilized Nanographene Oxide for Enhanced and Targeted Photothermal Therapy of Brain Cancer.

ACS Biomater Sci Eng. 2016-8-8

[2]
Near-Infrared-Triggered Photodynamic Therapy with Multitasking Upconversion Nanoparticles in Combination with Checkpoint Blockade for Immunotherapy of Colorectal Cancer.

ACS Nano. 2017-4-21

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ACS Nano. 2017-3-15

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Regul Toxicol Pharmacol. 2017-4

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ACS Nano. 2016-12-29

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Photodiagnosis Photodyn Ther. 2017-3

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Stabilization of Paclitaxel-Conjugated Micelles by Cross-Linking with Cystamine Compromises the Antitumor Effects against Two- and Three-Dimensional Tumor Cellular Models.

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[9]
Precise Targeting of Liver Tumor Using Glycol Chitosan Nanoparticles: Mechanisms, Key Factors, and Their Implications.

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[10]
Functionalized Carbon Nanotubes with Phosphorus- and Nitrogen-Containing Agents: Effective Reinforcer for Thermal, Mechanical, and Flame-Retardant Properties of Polystyrene Nanocomposites.

ACS Appl Mater Interfaces. 2016-9-21

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