Li Bingxia, Zhang Luna, Zhang Zichen, Gao Ruoqing, Li Hongmei, Dong Zhipeng, Wang Qiyan, Zhou Qingfa, Wang Yue
Key Laboratory of Biomedical Functional Materials, School of Sciences, China Pharmaceutical University Nanjing 211198 Jiangsu Province China
State Key Laboratory of Coordination Chemistry, Nanjing University Nanjing 210093 Jiangsu Province China.
RSC Adv. 2018 Jan 5;8(3):1693-1699. doi: 10.1039/c7ra12099k. eCollection 2018 Jan 2.
A synthetic method for preparing a Pluronic F127 (F127)-stabilized graphene (GO) supramolecular hydrogel as a safe nanovehicle for combination treatment has been studied. Doxorubicin (DOX) as a model drug is non-covalently bound on the great surface area of GO due to strong π-π interaction, hydrophobic interaction, and the strongest hydrogen bonding. drug release experiments revealed that this F127-stabilized GO supramolecular hydrogel has a sustained drug release characteristic. Furthermore, the supramolecular hydrogel showed better antitumor ability under NIR (near infrared) laser irradiation because of the excellent photothermal effect of GO. Moreover, we evaluated its antitumor ability and the results show that the hydrogel system can also markedly inhibit the growth of a tumor when administered individually, especially under laser irradiation. All these findings make the supramolecular hydrogel system promising for combination therapy with good bioavailability and minimal side effects.
研究了一种制备泊洛沙姆F127（F127）稳定的氧化石墨烯（GO）超分子水凝胶的合成方法，该水凝胶作为一种安全的纳米载体用于联合治疗。作为模型药物的阿霉素（DOX）由于强烈的π-π相互作用、疏水相互作用和最强的氢键作用，非共价结合在GO的大表面积上。药物释放实验表明，这种F127稳定的GO超分子水凝胶具有持续药物释放特性。此外，由于GO具有优异的光热效应，该超分子水凝胶在近红外（NIR）激光照射下显示出更好的抗肿瘤能力。此外，我们评估了其抗肿瘤能力，结果表明，该水凝胶系统单独给药时也能显著抑制肿瘤生长，尤其是在激光照射下。所有这些发现使得该超分子水凝胶系统有望用于联合治疗，具有良好的生物利用度和最小的副作用。
