Zhang Xu, Tan Bowen, Wu Yanting, Zhang Min, Liao Jinfeng
State Key Laboratory of Oral Diseases, National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Polymers (Basel). 2021 Jun 25;13(13):2100. doi: 10.3390/polym13132100.
Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.
光热疗法（PTT）是一种应对多重耐药菌感染和促进组织再生的有前景的策略。先前的研究表明，热疗可有效抑制细菌生长，而温和加热可促进细胞增殖，进而加速伤口愈合和骨再生。特别是，具有光热特性的水凝胶能够实现远程控制药物释放。在本综述中，我们介绍了水凝胶中用于光热效应的光热剂杂化物。我们还总结了光热水凝胶在抗菌作用、血管生成和成骨方面的潜在机制。此外，还介绍了光热水凝胶在伤口愈合和骨再生应用中的最新进展。最后，讨论了光热水凝胶的未来应用。具有光热效应的水凝胶为伤口愈合和骨再生提供了新方向，本综述将为组织工程提供参考。
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