通过一种意想不到的钯催化C-H官能化过程从伯苯乙胺制备吲哚啉。
Access to indolines from primary phenylethylamines by an unexpected palladium-catalyzed C-H functionalization process.
作者信息
Mancinelli Andrea, Albert Joan, Ariza Xavier, Barrios Leoní A, Garcia Jordi, Gómez Roberto, Granell Jaume
机构信息
Departament de Química Inorgànica i Orgànica, Secció de Química Orgànica, Facultat de Química, Universitat de Barcelona Martí i Franquès 1-11 08028 Barcelona Spain.
Institut de Biomedicina (IBUB), Universitat de Barcelona Barcelona Spain.
出版信息
RSC Adv. 2019 Aug 29;9(47):27176-27182. doi: 10.1039/c9ra05670j.
Abstract
A new method for the preparation of 2,2-disubstituted indolines from 2-phenylethylamines was developed under Pd catalysis and PhI(OAc) as oxidant. Imines derived from 2-pyridinecarboxaldehyde were formed to direct a C-H activation process. The resulting imines were also oxidized to the corresponding amides in the same Pd-catalyzed process to obtain the final indoline as a picolinamide.
摘要
在钯催化及以醋酸碘苯作为氧化剂的条件下，开发了一种由2-苯乙胺制备2,2-二取代吲哚啉的新方法。由2-吡啶甲醛衍生的亚胺形成后引导碳-氢键活化过程。在同一钯催化过程中，生成的亚胺还被氧化为相应的酰胺，以得到作为吡啶甲酰胺的最终吲哚啉。
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