Department of basic sciences, Faculty of Agriculture, University of Zalingei, Zalingei, Sudan.
H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Nat Prod Res. 2023 Jul-Aug;37(15):2473-2479. doi: 10.1080/14786419.2022.2050227. Epub 2022 Mar 11.
Six 5(14)-membered ring type of cyclopeptide alkaloids (CPAs), including two undescribed members, 1-hydro,2β-methoxy-mauritine-A () and 1-hydro,2α-methoxy-mauritine-A (), together with four known compounds, mauritine-A (), mauritine C (), amphibine-A (), and amphibine-E (), were isolated from the root bark of (L.) Desf., Their structures were determined by multiple spectral analyses, including UV, IR, 1D NMR, 2D NMR, EI-MS, HR-EI-MS, FAB-MS and ESI-MS, and by comparison with literature. All six CPAs were tested for cytotoxicity by three human cancer cell lines (MCF7, H460 and Hela) and a human normal cell line (BJ). None of the compounds showed cytotoxicity towards all tested cell lines.
六种五环型环肽生物碱（CPAs），包括两个未被描述的成员 1-羟，2β-甲氧基-毛里汀-A()和 1-羟，2α-甲氧基-毛里汀-A()，以及四种已知化合物毛里汀-A()、毛里汀 C()、两栖碱-A()和两栖碱-E()，从( L.) Desf.的根皮中分离出来。它们的结构通过多种光谱分析确定，包括 UV、IR、1D NMR、2D NMR、EI-MS、HR-EI-MS、FAB-MS 和 ESI-MS，并与文献进行了比较。所有六种 CPAs 均通过三种人癌细胞系（MCF7、H460 和 Hela）和一种人正常细胞系（BJ）进行了细胞毒性测试。这些化合物对所有测试的细胞系均无细胞毒性。
