使用炔铜（I）一锅法三组分合成5-烯丙基-1,2,3-三唑
One-pot three component synthesis of 5-allyl-1,2,3-triazoles using copper(i) acetylides.
作者信息
Reddy Parigi Raghavendar, Cui Lianji, Ryu Jae-Sang
机构信息
College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University 52 Ewhayeodae-gil, Seodaemun-Gu Seoul 03760 Republic of Korea
出版信息
RSC Adv. 2018 Jan 12;8(5):2759-2767. doi: 10.1039/c7ra12889d. eCollection 2018 Jan 9.
One-pot three-component reactions using copper(i) acetylide, azide, allyl iodide, and NaOH have been developed. The reactions proceed smoothly at room temperature to afford 5-allyl-1,2,3-triazoles, which can be further transformed into a variety of 1,2,3-triazole-fused bi-/tricyclic scaffolds. This method offers the most efficient, convenient, and practical route towards useful polycyclic scaffolds in moderate to excellent yields.
已开发出使用炔铜（I）、叠氮化物、烯丙基碘和氢氧化钠的一锅三组分反应。该反应在室温下顺利进行，生成5-烯丙基-1,2,3-三唑，其可进一步转化为多种1,2,3-三唑稠合的双环/三环骨架。该方法为获得有用的多环骨架提供了最有效、方便且实用的途径，产率适中至优异。
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