• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

采用选择性激光熔化技术制备的混合酸和热处理钛网的成骨能力。

Osteogenic capacity of mixed-acid and heat-treated titanium mesh prepared by a selective laser melting technique.

作者信息

Yamamoto Kayoko, Yamaguchi Seiji, Matsushita Tomiharu, Mori Shigeo, Hirata Azumi, Kato-Kogoe Nahoko, Nakano Hiroyuki, Nakajima Yoichiro, Nishitani Yoshihiro, Nagatsuka Hitoshi, Ueno Takaaki

机构信息

Division of Medicine for Function and Morphology of Sensor Organ, Dentistry and Oral Surgery, Osaka Medical College 2-7 Daigaku-machi Takatsuki City Osaka 569-8686 Japan

Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University Aichi Japan.

出版信息

RSC Adv. 2018 Jul 20;8(46):26069-26077. doi: 10.1039/c8ra04193h. eCollection 2018 Jul 19.

DOI:10.1039/c8ra04193h
PMID:35541945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9082758/
Abstract

The practical use of additive manufacturing to create artificial bone as a material for repairing complex bone defects is currently attracting attention. In this study, we compared the osteogenic capacity of materials composited by the method developed by Kokubo of treating 3D-printed titanium (Ti) mesh with a mixture of HSO and HCl and heating (mixed-acid and heat treatment) with that of materials subjected to conventional chemical treatment. Ti plates treated with this method have been found to promote highly active bone formation on their surface when inserted into rabbit tibial bone defects. No previous study has compared this method with other surface treatment methods. In this study, we used histological and other observations to compare the bone formation process in bone defects when Ti meshes prepared by the selective laser melting technique (SLM) and treated either with mixed acids and heat or with conventional chemical Ti surface treatments were implanted in a rat calvarial bone defect model. We found that both micro-computed tomography and observations of undecalcified ground sections showed that the best bone formation was observed in rats implanted with mesh treated with mixed acids and heat. Our results suggest that mixed-acid and heat-treated Ti mesh prepared by SLM may have a high osteogenic capacity in bone defects.

摘要

利用增材制造技术制造人工骨作为修复复杂骨缺损的材料的实际应用目前正受到关注。在本研究中，我们将通过Kokubo开发的用硫酸和盐酸混合物处理3D打印钛（Ti）网并加热（混合酸和热处理）的方法制备的复合材料的成骨能力与经过传统化学处理的材料的成骨能力进行了比较。已发现用这种方法处理的钛板插入兔胫骨骨缺损时可促进其表面形成高活性骨。以前没有研究将这种方法与其他表面处理方法进行比较。在本研究中，我们使用组织学和其他观察方法，比较了通过选择性激光熔化技术（SLM）制备并经混合酸和热处理或传统化学钛表面处理的钛网植入大鼠颅骨骨缺损模型时骨缺损处的骨形成过程。我们发现，微型计算机断层扫描和未脱钙磨片观察均显示，植入经混合酸和热处理的钛网的大鼠骨形成最佳。我们的结果表明，通过SLM制备的经混合酸和热处理的钛网在骨缺损中可能具有高成骨能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/a8f2c2aa5bb7/c8ra04193h-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/8cf8167276fb/c8ra04193h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/48e4f1ed7d97/c8ra04193h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/2be3ace87f69/c8ra04193h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/0342f46e2c31/c8ra04193h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/71e50b949cb9/c8ra04193h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/0edc96c7a7a7/c8ra04193h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/929be3c7712d/c8ra04193h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/e81ae2ba69bd/c8ra04193h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/6d891c278c6a/c8ra04193h-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/37d168cfc6f5/c8ra04193h-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/a8f2c2aa5bb7/c8ra04193h-f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/8cf8167276fb/c8ra04193h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/48e4f1ed7d97/c8ra04193h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/2be3ace87f69/c8ra04193h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/0342f46e2c31/c8ra04193h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/71e50b949cb9/c8ra04193h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/0edc96c7a7a7/c8ra04193h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/929be3c7712d/c8ra04193h-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/e81ae2ba69bd/c8ra04193h-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/6d891c278c6a/c8ra04193h-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/37d168cfc6f5/c8ra04193h-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8726/9082758/a8f2c2aa5bb7/c8ra04193h-f11.jpg

相似文献

1
Osteogenic capacity of mixed-acid and heat-treated titanium mesh prepared by a selective laser melting technique.采用选择性激光熔化技术制备的混合酸和热处理钛网的成骨能力。
RSC Adv. 2018 Jul 20;8(46):26069-26077. doi: 10.1039/c8ra04193h. eCollection 2018 Jul 19.
2
Mechanical, Histological, and Scanning Electron Microscopy Study of the Effect of Mixed-Acid and Heat Treatment on Additive-Manufactured Titanium Plates on Bonding to the Bone Surface.混合酸与热处理对增材制造钛板与骨表面结合影响的力学、组织学及扫描电子显微镜研究
Materials (Basel). 2020 Nov 12;13(22):5104. doi: 10.3390/ma13225104.
3
Bioactivation Treatment with Mixed Acid and Heat on Titanium Implants Fabricated by Selective Laser Melting Enhances Preosteoblast Cell Differentiation.混合酸和热对选择性激光熔化制造的钛植入物进行生物活化处理可增强前成骨细胞分化。
Nanomaterials (Basel). 2021 Apr 12;11(4):987. doi: 10.3390/nano11040987.
4
Histological Evaluation of Porous Additive-Manufacturing Titanium Artificial Bone in Rat Calvarial Bone Defects.多孔增材制造钛人工骨在大鼠颅骨缺损中的组织学评价
Materials (Basel). 2021 Sep 17;14(18):5360. doi: 10.3390/ma14185360.
5
Osseointegration of titanium scaffolds manufactured by selective laser melting in rabbit femur defect model.选择性激光熔化制造的钛支架在兔股骨缺损模型中的骨整合。
J Mater Sci Mater Med. 2019 Feb 12;30(2):26. doi: 10.1007/s10856-019-6227-9.
6
Improved osseointegration of 3D printed Ti-6Al-4V implant with a hierarchical micro/nano surface topography: An in vitro and in vivo study.具有分级微/纳表面形貌的 3D 打印 Ti-6Al-4V 植入物的骨整合改善：体外和体内研究。
Mater Sci Eng C Mater Biol Appl. 2021 Jan;118:111505. doi: 10.1016/j.msec.2020.111505. Epub 2020 Sep 11.
7
Enhancing the mechanical properties and surface morphology of individualized Ti-mesh fabricated through additive manufacturing for the treatment of alveolar bone defects.增强通过增材制造制备的个性化钛网的力学性能和表面形态以治疗牙槽骨缺损。
Front Bioeng Biotechnol. 2023 Nov 6;11:1284359. doi: 10.3389/fbioe.2023.1284359. eCollection 2023.
8
Bioactive Ti metal analogous to human cancellous bone: Fabrication by selective laser melting and chemical treatments.具有生物活性的类似于人松质骨的 Ti 金属：通过选择性激光熔化和化学处理来制造。
Acta Biomater. 2011 Mar;7(3):1398-406. doi: 10.1016/j.actbio.2010.09.034. Epub 2010 Sep 29.
9
Reconstruction of the Alveolar Bone Using Bone Augmentation With Selective Laser Melting Titanium Mesh Sheet: A Report of 2 Cases.使用选择性激光熔化钛网片进行骨增量重建牙槽骨：2 例报告。
Implant Dent. 2018 Oct;27(5):602-607. doi: 10.1097/ID.0000000000000822.
10
Bone regeneration by the osteoconductivity of porous titanium implants manufactured by selective laser melting: a histological and micro computed tomography study in the rabbit.采用选择性激光熔化制造的多孔钛植入物的骨传导性实现骨再生：兔的组织学和微计算机断层扫描研究。
Tissue Eng Part A. 2013 Dec;19(23-24):2645-54. doi: 10.1089/ten.TEA.2012.0753. Epub 2013 Sep 19.

引用本文的文献

1
Histological Evaluation of Porous Additive-Manufacturing Titanium Artificial Bone in Rat Calvarial Bone Defects.多孔增材制造钛人工骨在大鼠颅骨缺损中的组织学评价
Materials (Basel). 2021 Sep 17;14(18):5360. doi: 10.3390/ma14185360.
2
Bioactivation Treatment with Mixed Acid and Heat on Titanium Implants Fabricated by Selective Laser Melting Enhances Preosteoblast Cell Differentiation.混合酸和热对选择性激光熔化制造的钛植入物进行生物活化处理可增强前成骨细胞分化。
Nanomaterials (Basel). 2021 Apr 12;11(4):987. doi: 10.3390/nano11040987.
3
Mechanical, Histological, and Scanning Electron Microscopy Study of the Effect of Mixed-Acid and Heat Treatment on Additive-Manufactured Titanium Plates on Bonding to the Bone Surface.

本文引用的文献

1
Surface Modification of Porous Titanium Granules for Improving Bioactivity.用于提高生物活性的多孔钛颗粒的表面改性
Int J Oral Maxillofac Implants. 2016 Nov/Dec;31(6):1274-1280. doi: 10.11607/jomi.5246.
2
Bioactive treatment promotes osteoblast differentiation on titanium materials fabricated by selective laser melting technology.生物活性处理促进在选择性激光熔化技术制造的钛材料上的成骨细胞分化。
Dent Mater J. 2016;35(1):118-25. doi: 10.4012/dmj.2015-127.
3
Growth of Novel Ceramic Layers on Metals via Chemical and Heat Treatments for Inducing Various Biological Functions.
混合酸与热处理对增材制造钛板与骨表面结合影响的力学、组织学及扫描电子显微镜研究
Materials (Basel). 2020 Nov 12;13(22):5104. doi: 10.3390/ma13225104.
通过化学和热疗在金属上生长新型陶瓷层，以诱导各种生物功能。
Front Bioeng Biotechnol. 2015 Oct 27;3:176. doi: 10.3389/fbioe.2015.00176. eCollection 2015.
4
Osteoinduction on acid and heat treated porous Ti metal samples in canine muscle.犬类肌肉中经酸和热处理的多孔钛金属样品的骨诱导作用
PLoS One. 2014 Feb 10;9(2):e88366. doi: 10.1371/journal.pone.0088366. eCollection 2014.
5
Current barrier membranes: titanium mesh and other membranes for guided bone regeneration in dental applications.当前的屏障膜：钛网和其他用于牙科应用中的引导骨再生的膜。
J Prosthodont Res. 2013 Jan;57(1):3-14. doi: 10.1016/j.jpor.2012.12.001. Epub 2013 Jan 21.
6
Positively charged bioactive Ti metal prepared by simple chemical and heat treatments.通过简单的化学和热处理制备带正电荷的生物活性 Ti 金属。
J R Soc Interface. 2010 Oct 6;7 Suppl 5(Suppl 5):S503-13. doi: 10.1098/rsif.2010.0129.focus. Epub 2010 May 5.
7
Evaluation of 15 mandibular reconstructions with Dumbach Titan Mesh-System and particulate cancellous bone and marrow harvested from bilateral posterior ilia.使用Dumbach钛网系统以及取自双侧后髂骨的颗粒状松质骨和骨髓对15例下颌骨重建进行评估。
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Apr;107(4):e1-8. doi: 10.1016/j.tripleo.2008.12.018. Epub 2009 Feb 8.
8
Selective Laser Melting: a regular unit cell approach for the manufacture of porous, titanium, bone in-growth constructs, suitable for orthopedic applications.选择性激光熔化：一种用于制造适用于骨科应用的多孔钛骨生长结构的规则单胞方法。
J Biomed Mater Res B Appl Biomater. 2009 May;89(2):325-334. doi: 10.1002/jbm.b.31219.
9
"PASS" principles for predictable bone regeneration.可预测骨再生的“PASS”原则。
Implant Dent. 2006 Mar;15(1):8-17. doi: 10.1097/01.id.0000204762.39826.0f.
10
Osteoinductive porous titanium implants: effect of sodium removal by dilute HCl treatment.骨诱导性多孔钛植入物：稀盐酸处理去除钠的效果
Biomaterials. 2006 May;27(13):2682-91. doi: 10.1016/j.biomaterials.2005.12.014. Epub 2006 Jan 18.