• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于乙酰丙酮铟/乙二醇低共熔混合物介导的螺吡咯并[1,2 - ]异喹啉类似物的合成、表征及成骨细胞分化评估

ACI/EG eutectic mixture mediated synthesis, characterization and osteoblast differentiation assessment of spiropyrrolo[1,2-]isoquinoline analogues.

作者信息

Periyasami Govindasami, Arumugam Natarajan, Rahaman Mostafizur, Kumar Raju Suresh, Manikandan Muthurangan, Alfayez Musaad A, Premnath Dhanaraj, Aldalbahi Ali

机构信息

Department of Chemistry, College of Science, King Saud University P.O. Box 2455 Riyadh 11451 Saudi Arabia

Department of Organic Chemistry, University of Madras, Guindy Campus Chennai 600 025 India.

出版信息

RSC Adv. 2018 May 2;8(29):16303-16313. doi: 10.1039/c8ra00646f. eCollection 2018 Apr 27.

DOI:10.1039/c8ra00646f
PMID:35542235
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9080264/
Abstract

An eco-friendly acetylcholine iodide-ethylene glycol (ACI/EG) deep eutectic mixture mediated green protocol has been developed for the synthesis of hitherto unexplored multi-functionalized linear tricyclic spiropyrrolo[1,2-]isoquinoline analogues. The effects of the synthesized compounds on the osteoblast differentiation of hBMSC-TERT cell lines were investigated and promising results were observed with significant IC values. In addition, molecular modeling simulations were also performed with the 3D structure of BMP-2 to reveal binding interactions and orientations of highly potent spiropyrrolo[1,2-]isoquinoline analogues.

摘要

已开发出一种由环保型碘化乙酰胆碱 - 乙二醇（ACI/EG）低共熔混合物介导的绿色方法，用于合成迄今未被探索的多功能线性三环螺吡咯并[1,2 - ]异喹啉类似物。研究了合成化合物对hBMSC - TERT细胞系成骨细胞分化的影响，并观察到具有显著IC值的有前景的结果。此外，还利用BMP - 2的3D结构进行了分子模拟，以揭示高效螺吡咯并[1,2 - ]异喹啉类似物的结合相互作用和取向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/d4b3f8d1b0dd/c8ra00646f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/ec8d40a2e7d1/c8ra00646f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/66471dc39447/c8ra00646f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/596790639aa6/c8ra00646f-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/0776e936c47d/c8ra00646f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/a5ffa793e577/c8ra00646f-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/1a1de14cb2c1/c8ra00646f-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/386bdb2eabc0/c8ra00646f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/d87a1c842092/c8ra00646f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/b68ece97687b/c8ra00646f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/d4b3f8d1b0dd/c8ra00646f-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/ec8d40a2e7d1/c8ra00646f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/66471dc39447/c8ra00646f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/596790639aa6/c8ra00646f-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/0776e936c47d/c8ra00646f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/a5ffa793e577/c8ra00646f-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/1a1de14cb2c1/c8ra00646f-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/386bdb2eabc0/c8ra00646f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/d87a1c842092/c8ra00646f-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/b68ece97687b/c8ra00646f-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a8e/9080264/d4b3f8d1b0dd/c8ra00646f-f8.jpg

相似文献

1
ACI/EG eutectic mixture mediated synthesis, characterization and osteoblast differentiation assessment of spiropyrrolo[1,2-]isoquinoline analogues.基于乙酰丙酮铟/乙二醇低共熔混合物介导的螺吡咯并[1,2 - ]异喹啉类似物的合成、表征及成骨细胞分化评估
RSC Adv. 2018 May 2;8(29):16303-16313. doi: 10.1039/c8ra00646f. eCollection 2018 Apr 27.
2
An expeditious and environmentally benign synthesis of dispiro-3-phenylpyrrolothiazoles in ACI/EG eutectic mixture and its antioxidant and antimicrobial activities against urinary tract pathogens.在乙酰氯/乙二醇低共熔混合物中快速且环境友好地合成双螺-3-苯基吡咯并噻唑及其对尿路病原体的抗氧化和抗菌活性。
BMC Chem. 2019 Mar 28;13(1):42. doi: 10.1186/s13065-019-0553-3. eCollection 2019 Dec.
3
Stereoselective synthesis of dispiro heterocycles by [3 + 2] cycloaddition of azomethine ylides with a thiazolo[3,2-]indole derivative.通过氮宾叶立德与噻唑并[3,2-a]吲哚衍生物的[3 + 2]环加成反应立体选择性合成双螺杂环。
Org Biomol Chem. 2020 Oct 14;18(39):7822-7826. doi: 10.1039/d0ob01559h.
4
Diversity-Oriented Synthesis of Spiropyrrolo[1,2-]isoquinoline Derivatives via Diastereoselective and Regiodivergent Three-Component 1,3-Dipolar Cycloaddition Reactions: and Evaluation of the Antidiabetic Activity of Rhodanine Analogues.通过非对映选择性和区域选择性的三组分 1,3-偶极环加成反应进行导向多样性合成螺吡咯并[1,2-]异喹啉衍生物：和罗地那韦类似物的抗糖尿病活性评价。
J Org Chem. 2021 Oct 1;86(19):13420-13445. doi: 10.1021/acs.joc.1c01544. Epub 2021 Sep 21.
5
In vivo and in vitro toxicity profile of tetrabutylammonium bromide and alcohol-based deep eutectic solvents.四丁基溴化铵和醇基深共晶溶剂的体内和体外毒性特征。
Sci Rep. 2023 Jan 31;13(1):1777. doi: 10.1038/s41598-023-28928-y.
6
Synthesis of discrete aluminophosphate -CLO nanocrystals in a eutectic mixture.在共晶混合物中合成离散的磷酸铝-CLO 纳米晶体。
J Colloid Interface Sci. 2015 Aug 1;451:117-24. doi: 10.1016/j.jcis.2015.04.011. Epub 2015 Apr 11.
7
Are There Magic Compositions in Deep Eutectic Solvents? Effects of Composition and Water Content in Choline Chloride/Ethylene Glycol from Ab Initio Molecular Dynamics.深共晶溶剂中是否存在“魔法组合”？从从头算分子动力学看氯化胆碱/乙二醇中组成和含水量的影响。
J Phys Chem B. 2020 Aug 27;124(34):7433-7443. doi: 10.1021/acs.jpcb.0c04844. Epub 2020 Aug 14.
8
Novel, recyclable Brønsted acidic deep eutectic solvent for mild fractionation of hemicelluloses.新型可回收 Brønsted 酸性深共熔溶剂用于温和分馏半纤维素。
Carbohydr Polym. 2022 Feb 15;278:118992. doi: 10.1016/j.carbpol.2021.118992. Epub 2021 Dec 9.
9
Anatomy of Microscopic Structure of Ethaline Deep Eutectic Solvent Decoded through Molecular Dynamics Simulations.通过分子动力学模拟解析 Ethaline 深共晶溶剂的微观结构解剖。
J Phys Chem B. 2019 Oct 3;123(39):8291-8299. doi: 10.1021/acs.jpcb.9b06624. Epub 2019 Sep 18.
10
The eutectic point in choline chloride and ethylene glycol mixtures.胆碱氯化物和乙二醇混合物的共晶点。
Chem Commun (Camb). 2022 Nov 15;58(91):12728-12731. doi: 10.1039/d2cc04008e.

引用本文的文献

1
An expeditious and environmentally benign synthesis of dispiro-3-phenylpyrrolothiazoles in ACI/EG eutectic mixture and its antioxidant and antimicrobial activities against urinary tract pathogens.在乙酰氯/乙二醇低共熔混合物中快速且环境友好地合成双螺-3-苯基吡咯并噻唑及其对尿路病原体的抗氧化和抗菌活性。
BMC Chem. 2019 Mar 28;13(1):42. doi: 10.1186/s13065-019-0553-3. eCollection 2019 Dec.

本文引用的文献

1
Mild and General Synthesis of Pyrrolo[2,1-a]isoquinolines and Related Polyheterocyclic Frameworks from Pyrrole Precursors Derived from a Mechanochemical Multicomponent Reaction.温和且通用的吡咯并[2,1-a]异喹啉及其相关多杂环骨架的合成：源于机械化学多组分反应的吡咯前体。
J Org Chem. 2017 Mar 3;82(5):2570-2578. doi: 10.1021/acs.joc.6b02995. Epub 2017 Feb 22.
2
Characterization of Cellular and Molecular Heterogeneity of Bone Marrow Stromal Cells.骨髓基质细胞的细胞和分子异质性特征
Stem Cells Int. 2016;2016:9378081. doi: 10.1155/2016/9378081. Epub 2016 Aug 16.
3
Use of bone morphogenetic proteins in mesenchymal stem cell stimulation of cartilage and bone repair.
骨形态发生蛋白在间充质干细胞刺激软骨和骨修复中的应用。
World J Stem Cells. 2016 Jan 26;8(1):1-12. doi: 10.4252/wjsc.v8.i1.1.
4
Diverse Molecular Targets for Chalcones with Varied Bioactivities.具有多种生物活性的查耳酮的不同分子靶点。
Med Chem (Los Angeles). 2015 Aug;5(8):388-404. doi: 10.4172/2161-0444.1000291. Epub 2015 Aug 22.
5
Spirooxindole-derived morpholine-fused-1,2,3-triazoles: Design, synthesis, cytotoxicity and apoptosis inducing studies.螺环氧化吲哚衍生的吗啉稠合-1,2,3-三唑：设计、合成、细胞毒性及诱导凋亡研究
Eur J Med Chem. 2015 Sep 18;102:413-24. doi: 10.1016/j.ejmech.2015.08.017. Epub 2015 Aug 12.
6
Benzofuran-chalcone hybrids as potential multifunctional agents against Alzheimer's disease: synthesis and in vivo studies with transgenic Caenorhabditis elegans.苯并呋喃-查耳酮杂化物作为抗阿尔茨海默病的潜在多功能药物：合成及对转基因秀丽隐杆线虫的体内研究
ChemMedChem. 2014 Dec;9(12):2671-84. doi: 10.1002/cmdc.201402291. Epub 2014 Sep 24.
7
Iboga-Type Alkaloids from Ervatamia officinalis.从白花油麻藤中分离得到的伊博格碱型生物碱。
J Nat Prod. 2014 Aug 22;77(8):1839-46. doi: 10.1021/np500240b.
8
Visible-light photoredox catalyzed synthesis of pyrroloisoquinolines via organocatalytic oxidation/[3 + 2] cycloaddition/oxidative aromatization reaction cascade with Rose Bengal.可见光光氧化还原催化的通过有机催化氧化/[3 + 2]环加成/氧化芳构化反应级联反应合成吡咯并异喹啉，使用 Rose Bengal 作为光催化剂。
Beilstein J Org Chem. 2014 May 27;10:1233-8. doi: 10.3762/bjoc.10.122. eCollection 2014.
9
The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors.《2013/14药理学简明指南：催化受体》
Br J Pharmacol. 2013 Dec;170(8):1676-705. doi: 10.1111/bph.12449.
10
Receptor-targeted, magneto-mechanical stimulation of osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.受体靶向、磁机械刺激人骨髓间充质干细胞成骨分化。
Int J Mol Sci. 2013 Sep 23;14(9):19276-93. doi: 10.3390/ijms140919276.