基于乙酰丙酮铟/乙二醇低共熔混合物介导的螺吡咯并[1,2 - ]异喹啉类似物的合成、表征及成骨细胞分化评估
ACI/EG eutectic mixture mediated synthesis, characterization and osteoblast differentiation assessment of spiropyrrolo[1,2-]isoquinoline analogues.
作者信息
Periyasami Govindasami, Arumugam Natarajan, Rahaman Mostafizur, Kumar Raju Suresh, Manikandan Muthurangan, Alfayez Musaad A, Premnath Dhanaraj, Aldalbahi Ali
机构信息
Department of Chemistry, College of Science, King Saud University P.O. Box 2455 Riyadh 11451 Saudi Arabia
Department of Organic Chemistry, University of Madras, Guindy Campus Chennai 600 025 India.
出版信息
RSC Adv. 2018 May 2;8(29):16303-16313. doi: 10.1039/c8ra00646f. eCollection 2018 Apr 27.
An eco-friendly acetylcholine iodide-ethylene glycol (ACI/EG) deep eutectic mixture mediated green protocol has been developed for the synthesis of hitherto unexplored multi-functionalized linear tricyclic spiropyrrolo[1,2-]isoquinoline analogues. The effects of the synthesized compounds on the osteoblast differentiation of hBMSC-TERT cell lines were investigated and promising results were observed with significant IC values. In addition, molecular modeling simulations were also performed with the 3D structure of BMP-2 to reveal binding interactions and orientations of highly potent spiropyrrolo[1,2-]isoquinoline analogues.
已开发出一种由环保型碘化乙酰胆碱 - 乙二醇（ACI/EG）低共熔混合物介导的绿色方法，用于合成迄今未被探索的多功能线性三环螺吡咯并[1,2 - ]异喹啉类似物。研究了合成化合物对hBMSC - TERT细胞系成骨细胞分化的影响，并观察到具有显著IC值的有前景的结果。此外，还利用BMP - 2的3D结构进行了分子模拟，以揭示高效螺吡咯并[1,2 - ]异喹啉类似物的结合相互作用和取向。
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