Zou Chengye, Wei Xiaopeng, Zhang Qiang
School of Computer Science and Engineering, Dalian University of Technology Dalian 116024 China
Key Laboratory of Advanced and Intelligent Computing, Dalian University, Ministry of Education Dalian 116622 China.
RSC Adv. 2018 Jun 7;8(37):20941-20951. doi: 10.1039/c8ra01393d. eCollection 2018 Jun 5.
DNA strand displacement as a theoretic foundation is helpful in constructing reaction networks and DNA circuits. Research on chemical kinetics is significant to exploit the inherent potential property of biomolecular systems. In this study, we investigated two typical reactions and designed DNA strands with a fluorophore and dark quencher for reaction networks using a 3-variable Lotka-Volterra oscillator system as an example to show the convenience of and superiority for observation of dynamic trajectory using our design, and took advantage of the synchronization reaction module to synchronize two 3-variable Lotka-Volterra oscillators. The classical theory of chemical reaction networks can be used to represent biological processes for mathematical modeling. We used this method to simulate the nonlinear kinetics of a 3-variable Lotka-Volterra oscillator system.
以DNA链置换为理论基础有助于构建反应网络和DNA电路。化学动力学研究对于挖掘生物分子系统的内在潜在特性具有重要意义。在本研究中，我们研究了两个典型反应，并以一个三变量Lotka-Volterra振荡器系统为例，设计了带有荧光团和暗猝灭剂的DNA链用于反应网络，以展示我们设计在观察动态轨迹方面的便利性和优越性，并利用同步反应模块使两个三变量Lotka-Volterra振荡器同步。化学反应网络的经典理论可用于表示生物过程以进行数学建模。我们使用此方法模拟了三变量Lotka-Volterra振荡器系统的非线性动力学。
