Wu Fang, He Dengfeng, Chen Lei, Liu Fangqin, Huang Haolong, Dai Jiangshan, Zhang Shiyong, You Jingsong
National Engineering Research Center for Biomaterials, Sichuan University China.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University China.
RSC Adv. 2018 Jun 6;8(37):20829-20835. doi: 10.1039/c8ra00682b. eCollection 2018 Jun 5.
Herein, antibacterial coordination polymer hydrogels were conveniently fabricated in water coordination between silver nitrate and PEGylated bisimidazolylbenzyl alcohol (1a-c). These coordination polymer hydrogels exhibit much better antibacterial activity than silver nitrate against both Gram-negative and Gram-positive pathogens including multidrug-resistant pathogens. The coordination polymer Ag/1c with a long PEG chain (PEG1000) was demonstrated to be the most effective antibacterial material, and its minimum inhibition concentrations (MICs) could be as low as 15.2 times for common and 4.8 times for methicillin-resistant over that of silver nitrate. With improved antibacterial performance, easy preparation method, improved stability, sustained releasability, outstanding ductility and low cytotoxicity, the as-prepared coordination polymer hydrogels should find various potential applications such as in clinical burn and wound dressings, biofilms, bioadhesives, and coatings of biomedical materials.
在此，通过硝酸银与聚乙二醇化双咪唑基苄醇（1a - c）在水中的配位作用，简便地制备了抗菌配位聚合物水凝胶。这些配位聚合物水凝胶对革兰氏阴性菌和革兰氏阳性病原体（包括多重耐药病原体）均表现出比硝酸银更好的抗菌活性。具有长聚乙二醇链（PEG1000）的配位聚合物Ag/1c被证明是最有效的抗菌材料，其对常见菌的最低抑菌浓度（MICs）可低至硝酸银的15.2倍，对耐甲氧西林菌的最低抑菌浓度可低至硝酸银的4.8倍。所制备的配位聚合物水凝胶具有改进的抗菌性能、简便的制备方法、更高的稳定性、持续释放性、出色的延展性和低细胞毒性，应能在临床烧伤和伤口敷料、生物膜、生物粘合剂以及生物医学材料涂层等方面找到各种潜在应用。
