基于真黑素的5,6-二羟基吲哚-2-羧酸乙酯衍生物的便捷合成
Expedient synthesis of eumelanin-inspired 5,6-dihydroxyindole-2-carboxylate ethyl ester derivatives.
作者信息
Aebly Andrew H, Levy Jeffrey N, Steger Benjamin J, Quirke Jonathan C, Belitsky Jason M
机构信息
Department of Chemistry and Biochemistry, Oberlin College 119 Woodland St. Oberlin OH 44074 USA
出版信息
RSC Adv. 2018 Aug 7;8(50):28323-28328. doi: 10.1039/c8ra06148c.
Dihydroxyindoles such as 5,6-dihydroxyindole-2-carboxylic acid (DHICA) are the main monomer units of eumelanin, the black to brown pigment in humans, and have emerging biological roles beyond melanin. Elaboration of commercially available 5,6-dimethoxy-2-carboxylate ethyl ester provides ready access to DHICA-inspired small molecules, including 3-(hetero)aryl-indoles and 4,7-di-(hetero)aryl-indoles.
二羟基吲哚，如5,6 - 二羟基吲哚 - 2 - 羧酸（DHICA）是真黑素的主要单体单元，真黑素是人类体内黑色至棕色的色素，并且除了黑色素之外还具有新出现的生物学作用。对市售的5,6 - 二甲氧基 - 2 - 羧酸乙酯进行修饰可方便地获得受DHICA启发的小分子，包括3 - （杂）芳基吲哚和4,7 - 二 - （杂）芳基吲哚。
Zotero 插件